{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:38:25Z","timestamp":1773308305276,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2000,5,1]],"date-time":"2000-05-01T00:00:00Z","timestamp":957139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2000,5]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> A functional polymorphism of the interleukin\u20101 beta (IL\u20101\u03b2) gene has been proposed to be a risk factor for periodontitis. In adult forms of periodontitis, non\u2010smokers of northern European heritage carrying the \u201c2\u201d allele of the IL\u20101\u03b1\u2010889 and the IL\u20101\u03b2 +3953 RFLPs in either the heterozygous or the homozyous state at both loci were observed to have a greater risk for developing severe periodontitis. Studies of early\u2010onset periodontitis (EOP) found that allele \u201c1\u201d of both IL\u20101alpha;\u2010889 and IL\u20101\u03b2 +3953 was transmitted more frequently with the EOP phenotype. The purpose of the present study was to determine the prevalence of the IL\u20101\u03b1 and IL\u20101\u03b2 genotype polymorphisms in an African\u2010American (AA) control population and in 37 African\u2010Americans with localized juvenile periodontitis (LJP).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The IL\u20101\u03b1 +4845 and IL\u20101\u03b2 +3953 loci were genotyped by PCR amplification, followed by restriction enzyme digestion and gel electrophoresis. The IL\u20101\u03b1 +4845 locus, in linkage disequilibrium (&gt;99%) with IL\u20101\u03b1\u2010889, was genotyped because it is technically easier. Data were analyzed using r \u00d7 c contingency tables.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The IL\u20101\u03b2 +3953 allele \u201c1\u201d was carried by &gt;99% of the AA control population and by 100% of the AA LJP group, with most individuals being homozygous 1,1. The prevalence of the composite genotype with at least one allele \u201c2\u201d at each of the IL\u20101\u03b2 +3953 and IL\u20101\u03b1 +4845 loci was 14% (AA control group) and 8% (AA LJP group).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Given the high frequency of the IL\u20101\u03b2 allele \u201c1\u201d in the African\u2010American population, it would appear that knowledge of this +3953 polymorphism would provide little diagnostic or predictive information for LJP. <jats:italic>J Periodontol 2000;71:723\u2010728.<\/jats:italic><\/jats:p>","DOI":"10.1902\/jop.2000.71.5.723","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T06:31:29Z","timestamp":1107325889000},"page":"723-728","source":"Crossref","is-referenced-by-count":75,"title":["Genetic Polymorphisms of the IL\u20101\u03b1 and IL\u20101\u03b2 Genes in African\u2010American LJP Patients and an African\u2010American Control Population"],"prefix":"10.1002","volume":"71","author":[{"given":"Stephen J.","family":"Walker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas E.","family":"Van Dyke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Rich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth S.","family":"Kornman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.S.","family":"di Giovine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas C.","family":"Hart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2000,5]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2000.71.5.723","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:36:37Z","timestamp":1760873797000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2000.71.5.723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,5]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2000,5]]}},"alternative-id":["10.1902\/jop.2000.71.5.723"],"URL":"https:\/\/doi.org\/10.1902\/jop.2000.71.5.723","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,5]]}}}