{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:10:08Z","timestamp":1792656608670,"version":"4.5.0"},"reference-count":0,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2000,7]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Biodegradable materials have been successfully utilized for guided tissue regeneration (GTR) and local delivery systems (LDS) because they are biocompatible, less cytotoxic, and do not require removal. Several studies have demonstrated that tetracyclines (TCs), when applied topically, stimulated osteogenesis in experimental bone defects. The purpose of this study was to evaluate the regenerative effect of a 25% doxycycline\u2010loaded biodegradable GTR membrane (Doxy\u2010M) in dogs.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Doxy\u2010M was made by coating the inner surface of a biodegradable membrane (BD\u2010M) with 25% doxycycline. Five male mongrel dogs with 20 created osseous defects were enrolled. The plain BD\u2010M was used as the control membrane. Either Doxy\u2010M or BD\u2010M was applied in 20 randomly selected defects (10 Doxy\u2010M, 10 BD\u2010M) for 12 weeks with the GTR technique. The histometric analysis was evaluated with the following parameters: defect height (DH), apical extension of junctional epithelium (AEJP), new cementum height (NCH), new bone height (NBH), and new bone area (NBA).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    The Doxy\u2010M\u2013treated defects showed more pronounced new bone formation and less crestal bone resorption than the BD\u2010M\u2013treated defects. There were no statistically significant differences between the two groups in DH, AEJP, and NCH. Statistically significantly larger NBH (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05) and NBA (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.005) were seen in the Doxy\u2010M\u2013treated defects.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    The results strongly suggest that Doxy\u2010M may have a beneficial effect on osteogenesis to favor periodontal regeneration.\n                    <jats:italic>J Periodontol 2000;71:1086\u20101093.<\/jats:italic>\n                  <\/jats:p>","DOI":"10.1902\/jop.2000.71.7.1086","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T06:36:05Z","timestamp":1107326165000},"page":"1086-1093","source":"Crossref","is-referenced-by-count":39,"title":["Evaluation of the Regenerative Effect of a 25% Doxycycline\u2010Loaded Biodegradable Membrane for Guided Tissue Regeneration"],"prefix":"10.1002","volume":"71","author":[{"given":"Chao\u2010Yi","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2000,7]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2000.71.7.1086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:39:11Z","timestamp":1760873951000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2000.71.7.1086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2000,7]]}},"alternative-id":["10.1902\/jop.2000.71.7.1086"],"URL":"https:\/\/doi.org\/10.1902\/jop.2000.71.7.1086","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,7]]}}}