{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T06:44:43Z","timestamp":1764053083532,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2000,9]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The present study investigated the possible influence of nicotine on the bone loss rate in the furcation region due to ligature\u2010induced periodontitis in rats.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Twenty adult male Wistar rats were included. After anesthesia, the tooth was randomly assigned to receive the cotton ligature in the sulcular area, while the contralateral tooth was left unligated. The animals were randomly assigned to one of the following treatments, including daily intraperitoneal injections: group A, 2 \u03bcl\/g body weight of saline solution; group B, 2 \u03bcl\/g body weight of a nicotine solution with 0.13 \u03bcl of nicotine\/ml of saline solution; group C, 2 \u03bcl\/g body weight of a nicotine solution with 0.19 \u03bcl of nicotine\/ml of saline solution; and group D, 2 \u03bcl\/g body weight of a nicotine solution with 0.26 \u03bcl of nicotine\/ml of saline solution. Thirty days later, the animals were sacrificed and the specimens routinely processed for serial decalcified sections.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Intergroup analysis revealed greater bone loss in the ligated teeth of group B (1.01 \u00b1 0.61 mm<jats:sup>2<\/jats:sup>), group C (1.14 \u00b1 0.72 mm<jats:sup>2<\/jats:sup>), and group D (1.36 \u00b1 0.60 mm<jats:sup>2<\/jats:sup>) when compared with group A (0.64 \u00b1 0.62 mm<jats:sup>2<\/jats:sup>) (<jats:italic>P<\/jats:italic> &lt;0.01). However, no statistically significant differences in bone loss were found among groups B, C, and D. In addition, no bone loss was observed for unligated teeth (<jats:italic>P<\/jats:italic> &gt;0.01).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Within the limits of the present study, nicotine enhanced the effects of the local components of periodontal disease in a non\u2010dose\u2010dependent way; nevertheless, the administration of nicotine did not produce periodontal bone loss by itself. <jats:italic>J Periodontol 2000;71:1460\u20101464.<\/jats:italic><\/jats:p>","DOI":"10.1902\/jop.2000.71.9.1460","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T06:37:42Z","timestamp":1107326262000},"page":"1460-1464","source":"Crossref","is-referenced-by-count":43,"title":["The Influence of Nicotine on the Bone Loss Rate in Ligature\u2010Induced Periodontitis. A Histometric Study in Rats"],"prefix":"10.1002","volume":"71","author":[{"suffix":"Jr.","given":"Francisco H.","family":"Nociti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Get\u00falio R.","family":"Nogueira\u2010Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana T.","family":"Primo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria A.N.","family":"Machado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vin\u00edcius A.","family":"Tramontina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvana P.","family":"Barros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enilson A.","family":"Sallum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2000,9]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2000.71.9.1460","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:05:42Z","timestamp":1760871942000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2000.71.9.1460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2000,9]]}},"alternative-id":["10.1902\/jop.2000.71.9.1460"],"URL":"https:\/\/doi.org\/10.1902\/jop.2000.71.9.1460","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"type":"print","value":"0022-3492"},{"type":"electronic","value":"1943-3670"}],"subject":[],"published":{"date-parts":[[2000,9]]}}}