{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T13:26:33Z","timestamp":1773235593149,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The purpose of the present parallel design, controlled clinical trial was to evaluate the treatment outcome following flap debridement surgery (FDS) in cigarette smokers compared to non\u2010smokers.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> After initial therapy, 57 systemically healthy subjects with moderate to advanced periodontitis who presented with one area (at least 3 teeth) where surgery was required were selected. Twenty\u2010eight patients (mean age: 39.6 years, 20 males) were smokers (\u226510 cigarettes\/day); 29 patients (mean age: 43.9 years, 7 males) were non\u2010smokers. Full\u2010mouth plaque (FMP) and bleeding on probing (BOP) scores, probing depth (PD), clinical attachment level (CAL), and recession depth (RD) were assessed immediately before and 6 months following surgery. Only sites with presurgery PD \u22654 mm were used for statistical analysis.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Presurgery FMP and BOP were similar in smokers and non\u2010smokers and significantly decreased postsurgery in both groups. Overall, PD reduction and CAL gain were greater, although not significantly, in non\u2010smokers (2.4 \u00b10.9 mm and 1.6 \u00b10.7 mm, respectively) than in smokers (1.9 \u00b10.7 mm and 1.2 \u00b10.7 mm, respectively). For moderate sites (PD 4 to 6 mm), no significant differences in PD and CAL changes were found between groups. For deep sites (PD \u22657 mm), PD reduction was 3.0 \u00b11.0 mm in smokers and 4.0 \u00b10.8 mm in non\u2010smokers, and CAL gain amounted to 1.8 \u00b11.1 mm in smokers and 2.8 \u00b11.0 mm in nonsmokers (<jats:italic>P<\/jats:italic> = 0.0477). In smokers, 16% of deep sites healed to postsurgery PD values \u22643 mm as compared to 47% in non\u2010smokers (<jats:italic>P<\/jats:italic> = 0.0000); 58% of deep sites in smokers showed a CAL gain \u22652 mm, as compared to 82% in non\u2010smokers (<jats:italic>P<\/jats:italic> = 0.0000).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Results of the study indicated that: 1) FDS determined a statistically significant PD reduction and CAL gain in patients with moderate to advanced periodontitis; 2) smokers exhibited a trend towards less favorable healing response following FDS compared to non\u2010smokers, both in terms of PD reduction and CAL gain; and 3) this trend reached clinical and statistical significance at sites with initial deep PD. <jats:italic>J Periodontol 2001;72:43\u201049.<\/jats:italic><\/jats:p>","DOI":"10.1902\/jop.2001.72.1.43","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T06:40:45Z","timestamp":1107326445000},"page":"43-49","source":"Crossref","is-referenced-by-count":81,"title":["Cigarette Smoking Negatively Affects Healing Response Following Flap Debridement Surgery"],"prefix":"10.1002","volume":"72","author":[{"given":"Alessandro","family":"Scabbia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoo\u2010Sung","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thorarinn J.","family":"Sigurdsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong\u2010Kwan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Trombelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,1]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2001.72.1.43","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:24:47Z","timestamp":1760865887000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2001.72.1.43"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2001,1]]}},"alternative-id":["10.1902\/jop.2001.72.1.43"],"URL":"https:\/\/doi.org\/10.1902\/jop.2001.72.1.43","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,1]]}}}