{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T23:04:08Z","timestamp":1771369448626,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2001,10,1]],"date-time":"2001-10-01T00:00:00Z","timestamp":1001894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2001,10]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Functional polymorphisms of immunoglobulin G (IgG) Fc receptors (Fc\u03b3R) have been shown to be associated with generalized aggressive periodontitis (GAgP) or recurrence of chronic periodontitis (CP) in Japanese patients. The purpose of this study was to evaluate whether Fc\u03b3R polymorphisms are also associated with severity of CP.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Fifty Japanese non\u2010smoking patients with severe CP and 39 Japanese non\u2010smoking patients with moderate CP were identified according to established clinical criteria, including measurements of probing depth (PD), clinical attachment level (CAL), and alveolar bone loss (BL). Fc\u03b3R genotypes for 3 bi\u2010allelic polymorphisms (Fc\u03b3RIIa\u2010R\/H131, Fc\u03b3RIIIa\u2010158V\/F, Fc\u03b3RIIIb\u2010NA1\/NA2) were determined in these CP patients and 64 race\u2010matched, non\u2010smoking healthy controls by means of allele\u2010specific polymerase chain reactions.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> There was a significant over\u2010representation of Fc\u03b3RIIIa\u2010158V allele in severe CP patients compared to moderate CP patients (odds ratio 2.03, 95% confidence interval [CI] 1.03\u20104.01, <jats:italic>\u03c7<\/jats:italic> <jats:sup>2<\/jats:sup> = 4.86, <jats:italic>P<\/jats:italic> = 0.028). In addition, we found a strong association between CP severity and Fc\u03b3R composite genotype comprising Fc\u03b3RIIIa\u2010158V plus Fc\u03b3RIIIb\u2010NA2 (severe CP versus moderate CP: odds ratio 4.69, 95% CI 1.52\u201015.10, <jats:italic>\u03c7<\/jats:italic> <jats:sup>2<\/jats:sup> = 9.35, <jats:italic>P<\/jats:italic> = 0.002; severe CP versus healthy controls: odds ratio 4.10, 95% CI 1.62\u201010.59, <jats:italic>\u03c7<\/jats:italic> <jats:sup>2<\/jats:sup> = 11.13, <jats:italic>P<\/jats:italic> = 0.0009). Moreover, CP patients positive for the composite genotype exhibited more severe signs of periodontitis than composite genotype\u2010negative individuals (positive versus negative; mean PD: 3.8 mm versus 3.2 mm, <jats:italic>P<\/jats:italic> = 0.005; mean CAL: 4.5 mm versus 3.7 mm, <jats:italic>P<\/jats:italic> = 0.005; mean % BL: 37.6% versus 29.9%, <jats:italic>P<\/jats:italic> = 0.008).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Our results document the Fc\u03b3RIIIa\u2010158V allele and possibly Fc\u03b3RIIIb\u2010NA2 to be associated with severity of CP in Japanese patients. <jats:italic>J Periodontol 2001;72:1324\u20101331.<\/jats:italic><\/jats:p>","DOI":"10.1902\/jop.2001.72.10.1324","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T06:43:44Z","timestamp":1107326624000},"page":"1324-1331","source":"Crossref","is-referenced-by-count":62,"title":["The Fc\u03b3 Receptor Genotype as a Severity Factor for Chronic Periodontitis in Japanese Patients"],"prefix":"10.1002","volume":"72","author":[{"given":"Tetsuo","family":"Kobayashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouji","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Sugita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W\u2010Ludo","family":"van der Pol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Yasuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan G. J.","family":"van de Winkel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromasa","family":"Yoshie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,10]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2001.72.10.1324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T14:34:56Z","timestamp":1760884496000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2001.72.10.1324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,10]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2001,10]]}},"alternative-id":["10.1902\/jop.2001.72.10.1324"],"URL":"https:\/\/doi.org\/10.1902\/jop.2001.72.10.1324","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,10]]}}}