{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T15:45:55Z","timestamp":1762443955529,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2001,12,1]],"date-time":"2001-12-01T00:00:00Z","timestamp":1007164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2001,12]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Periodontal diseases are viewed today as multifactorial problems initiated and sustained by bacteria but significantly modified by the body's response to bacterial plaque. A recent study suggested that receptor for advanced glycation end products (RAGE) could be involved in the pathophysiology of periodontitis. The aim of this study was to investigate a possible association of 3 common polymorphisms in the RAGE gene with chronic periodontitis.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> We studied 101 Caucasian patients with chronic periodontitis together with 162 orally healthy subjects. Three polymorphisms, one in intron 7 (1704G\/T), second in intron 8 (2184A\/G), and the third in exon 3 (G82S) of the RAGE gene, were investigated by polymerase chain reaction methods (PCR) with subsequent enzymatic restriction with BfaI, BsmFI, or AluI, respectively.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> A statistically significant difference in allele frequencies between patients and the reference group was found for intron variant 1704G\/T (<jats:italic>P<\/jats:italic> = 0.02, <jats:italic>P<\/jats:italic><jats:sub>corr<\/jats:sub> &gt;0.05). There was no significant difference in genotype or allele frequency distributions between groups for intron variant 2184A\/G or for the exon variant exchanging amino acid Gly for Ser at position 82 (G82S).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> We can speculate that susceptibility to the development of chronic periodontitis could be influenced by the 1704G\/T polymorphism of the RAGE gene, independently of diabetes. <jats:italic>J Periodontol 2001;72:1742\u20101746.<\/jats:italic><\/jats:p>","DOI":"10.1902\/jop.2001.72.12.1742","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T06:48:16Z","timestamp":1107326896000},"page":"1742-1746","source":"Crossref","is-referenced-by-count":34,"title":["Distribution of the Receptor for Advanced Glycation End Products Gene Polymorphisms in Patients With Chronic Periodontitis: A Preliminary Study"],"prefix":"10.1002","volume":"72","author":[{"given":"Lydie Izakovi\u010dov\u00e1","family":"Holl\u00e1","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate\u0159ina","family":"Ka\u0148kov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton\u00edn","family":"Fassmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana","family":"Bu\u010dkov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom\u00e1\u0161","family":"Halabala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladim\u00edr","family":"Znojil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji\u0159\u00ed","family":"Van\u011bk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2001.72.12.1742","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:44:58Z","timestamp":1760874298000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2001.72.12.1742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2001,12]]}},"alternative-id":["10.1902\/jop.2001.72.12.1742"],"URL":"https:\/\/doi.org\/10.1902\/jop.2001.72.12.1742","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"type":"print","value":"0022-3492"},{"type":"electronic","value":"1943-3670"}],"subject":[],"published":{"date-parts":[[2001,12]]}}}