{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T09:49:00Z","timestamp":1781603340570,"version":"3.54.5"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,2,1]],"date-time":"2001-02-01T00:00:00Z","timestamp":980985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2001,2]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Relative few reports exist concerning healing of laser created osteotomies over an extended period of time. The purpose of this study was to evaluate long\u2010term healing, from 21 to 63 days, of osteotomy defects in the rat tibia created with the Nd:YAG and CO<jats:sub>2<\/jats:sub> in the presence of a surface cooling spray of air\/water.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The experimental model consisted of 15 large Sprague\u2010Dawley rats. Six treatment modalities were randomly distributed among 6 tibial recipient sites: 1) a negative control (no treatment); 2) a positive control (bur osteotomy); 3) CO<jats:sub>2<\/jats:sub> laser at 5 W (860 J\/cm<jats:sup>2<\/jats:sup>); 4) CO<jats:sub>2<\/jats:sub> laser at 6 W (1032 J\/cm<jats:sup>2<\/jats:sup>); 5) Nd:YAG laser at 5 W (714 J\/cm<jats:sup>2<\/jats:sup>); and 6) Nd:YAG laser at 7 W (1000 J\/cm<jats:sup>2<\/jats:sup>). All laser irradiation was delivered in the presence of a surface coolant consisting of air (15 psi) and sterile water. Five animals were sacrificed at each of 3 time intervals: 21, 35, and 63 days post\u2010treatment. Multiple histologic sections from each treatment site were examined by light microscopy using hematoxylin and eosin Goldner's trichrome stains, and polarized light and evaluated for presence of a char layer, heat induced cracking, heat related alterations in cells or tissue matrix, and osseous regeneration.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Healing was severely delayed in all laser treated sites compared to positive control sites. Of the laser treated sites, those irradiated by CO<jats:sub>2<\/jats:sub> laser at 5 W (780 J\/cm<jats:sup>2<\/jats:sup>) exhibited the greater amount of bone regeneration. At best, however, only a small percentage of sections from any of the laser treated specimens showed evidence of bone regeneration within the ablation defect regardless of the post\u2010treatment time interval.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Under the conditions of this study, the osseous healing response was severely delayed by CO<jats:sub>2<\/jats:sub> and Nd:YAG laser irradiation of bone, even in the presence of a surface cooling spray of air\/water. <jats:italic>J Periodontol 2001;72:174\u2010182.<\/jats:italic><\/jats:p>","DOI":"10.1902\/jop.2001.72.2.174","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T06:49:51Z","timestamp":1107326991000},"page":"174-182","source":"Crossref","is-referenced-by-count":37,"title":["Laser Irradiation of Bone: III. Long\u2010Term Healing Following Treatment by CO<sub>2<\/sub> and Nd:YAG Lasers"],"prefix":"10.1002","volume":"72","author":[{"given":"Valerie G.","family":"McDavid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles M.","family":"Cobb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Rapley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan G.","family":"Glaros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulette","family":"Spencer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,2]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2001.72.2.174","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:51:39Z","timestamp":1760878299000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2001.72.2.174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,2]]}},"alternative-id":["10.1902\/jop.2001.72.2.174"],"URL":"https:\/\/doi.org\/10.1902\/jop.2001.72.2.174","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,2]]}}}