{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T13:18:27Z","timestamp":1773148707310,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,2,1]],"date-time":"2001-02-01T00:00:00Z","timestamp":980985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2001,2]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Alendronate (ALN) is an aminobisphosphonate commonly used for osteoporosis in postmenopausal women. We studied the effect of ALN on bone loss prevention in type 2 diabetes mellitus patients with periodontal disease.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> In a controlled double\u2010blind, randomized study we evaluated prospectively diabetic patients paired by gender and years since diagnosis for 6 months. The study included 40 patients (20 men and 20 women), 50 to 60 years old, with more than 5 years since diagnosis of diabetes and established periodontitis. They were randomly allocated to alendronate (10 mg\/daily) or placebo treatment for 6 months. The endpoints of treatment were: the distance between the alveolar bone border and the cemento\u2010enamel\u2010junction (CEJ) evaluated by means of digital radiographic imaging, a biochemical marker of bone resorption (urine N\u2010telopeptide) (Ntx), and periodontal parameters. Metabolic control was assessed at baseline and after 6 months.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Baseline and 6\u2010month glycated hemoglobin levels were similar in both groups. Alendronate induced a significant decrease in NTx at 6 months (<jats:italic>P<\/jats:italic> = 0.006). Periodontal parameters improved in both groups. However, they were significantly better for the ALN treated group. Alveolar bone border\u2010CEJ distance increased in the placebo, but decreased in the ALN group (<jats:italic>P<\/jats:italic> = 0.0003).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> In type\u20102 diabetic patients, alendronate induced more improvement in alveolar bone crest height than control therapy. No differences in urinary N\u2010telopeptide or glycated hemoglobin were observed in this short\u2010term randomized controlled pilot trial. <jats:italic>J Periodontol 2001;72:204\u2010209.<\/jats:italic><\/jats:p>","DOI":"10.1902\/jop.2001.72.2.204","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T06:49:51Z","timestamp":1107326991000},"page":"204-209","source":"Crossref","is-referenced-by-count":96,"title":["Clinical and Radiological Improvement of Periodontal Disease in Patients With Type 2 Diabetes Mellitus Treated With Alendronate: A Randomized, Placebo\u2010Controlled Trial"],"prefix":"10.1002","volume":"72","author":[{"given":"Miriam","family":"Rocha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura Eugenia","family":"Nava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos V\u00e1zquez","family":"de la Torre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"S\u00e1nchez\u2010Mar\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma. Eugenia","family":"Garay\u2010Sevilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Manuel","family":"Malacara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,2]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2001.72.2.204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:51:38Z","timestamp":1760878298000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2001.72.2.204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,2]]}},"alternative-id":["10.1902\/jop.2001.72.2.204"],"URL":"https:\/\/doi.org\/10.1902\/jop.2001.72.2.204","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,2]]}}}