{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:33:44Z","timestamp":1762954424424,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2001,4,1]],"date-time":"2001-04-01T00:00:00Z","timestamp":986083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2001,4]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The aim of the present study was to investigate the level of transforming growth factor\u2010\u03b21 (TGF\u2010\u03b21) in gingival crevicular fluid (GCF) samples of cyclosporin A (CsA)\u2010treated patients and to compare the results with control groups.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Fourteen renal transplant patients exhibiting severe CsA\u2010induced gingival overgrowth, 10 patients with chronic gingivitis, and 10 subjects with clinically healthy periodontium were included in the study. In CsA\u2010treated patients, GCF samples were harvested from sites exhibiting gingival overgrowth (CsA GO+) and sites not exhibiting gingival overgrowth (CsA GO\u2010). The TGF\u2010\u03b21 levels in a total of 96 GCF samples from the 34 participants were analyzed by enzyme\u2010linked immunosorbent assay. The results were expressed in terms of total amount (pg\/2 sites) and concentration (ng\/ml).<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> TGF\u2010\u03b21 total amounts in CsA GO+ and CsA GO\u2212 sites were similar and significantly higher than that of healthy sites (<jats:italic>P<\/jats:italic> &lt;0.02 and <jats:italic>P<\/jats:italic> &lt;0.01, respectively). The total amount of TGF\u2010\u03b21 was also higher in gingivitis sites compared to the healthy sites, but the difference was not statistically significant (<jats:italic>P<\/jats:italic> &gt;0.05). CsA GO+ and CsA GO\u2010 sites exhibited higher total amount and concentration of TGF\u2010\u03b21 than that of gingivitis sites, but the differences were insignificant (<jats:italic>P<\/jats:italic> &gt;0.05).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> The results of the present study support the theory that CsA increases the synthesis of TGF\u2010\u03b21 in GCF. However, since the difference between CsA GO+ and CsA GO\u2010 sites was not statistically significant, it seems unlikely that GCF TGF\u2010\u03b21 level is the sole factor responsible for the CsA\u2010induced gingival overgrowth. Complex interactions between various mediators of inflammation and tissue modeling are possibly involved in the pathogenic mechanisms of this side effect. <jats:italic>J Periodontol 2001;72:526\u2010531.<\/jats:italic><\/jats:p>","DOI":"10.1902\/jop.2001.72.4.526","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T06:53:23Z","timestamp":1107327203000},"page":"526-531","source":"Crossref","is-referenced-by-count":45,"title":["Evaluation of Transforming Growth Factor\u2010\u03b21 Level in Crevicular Fluid of Cyclosporin A\u2010Treated Patients"],"prefix":"10.1002","volume":"72","author":[{"given":"Nurcan","family":"Buduneli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Necil","family":"K\u00fct\u00fck\u00e7\u00fcler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fczide","family":"Aksu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcl","family":"Atilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,4]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2001.72.4.526","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:26:57Z","timestamp":1760869617000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2001.72.4.526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,4]]}},"alternative-id":["10.1902\/jop.2001.72.4.526"],"URL":"https:\/\/doi.org\/10.1902\/jop.2001.72.4.526","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"type":"print","value":"0022-3492"},{"type":"electronic","value":"1943-3670"}],"subject":[],"published":{"date-parts":[[2001,4]]}}}