{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:33:56Z","timestamp":1760920436200,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2001,5,1]],"date-time":"2001-05-01T00:00:00Z","timestamp":988675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2001,5]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The present study aimed to explain the interindividual variation in periodontitis susceptibility by differences in the initial adhesion rate of <jats:italic>Porphyromonas gingivalis<\/jats:italic> to the pocket epithelium of these individuals, and\/or by inter\u2010<jats:italic>P. gingivalis<\/jats:italic> strain differences in association capacity (adhesion and internalization).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Adhesion assays were performed on epithelial monolayers (cultured in vitro from pocket epithelium belonging to patients who were less or more susceptible to chronic adult periodontitis) using 11 genetically different clinical strains of <jats:italic>P. gingivalis<\/jats:italic><\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Both the disease category (less susceptible versus susceptible) and the interstrain variation were found to have a significant effect (both P &lt;0.05) on the initial bacterial association. The chronic adult periodontitis group showed significantly more association of <jats:italic>P. gingivalis<\/jats:italic> when compared to less susceptible patients (4.2 \u00d7 106 versus 3.5 \u00d7 106). Also, the interstrain variation was significant, with strains <jats:italic>Pg<\/jats:italic> 4 and 5 representing the least and best associating bacteria (1.8 \u00d7 10<jats:sup>6<\/jats:sup> colony forming units for Pg 4, 9 \u00d7 106 for Pg 5).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> These results indicate that periodontitis susceptibility is influenced by both the interindividual differences in pocket epithelium (allowing more adhesion of <jats:italic>P. gingivalis<\/jats:italic>) or by the strain type by which the patient is infected (intra\u2010species differences in adhesion capacity). <jats:italic>J Periodontol 2001;72:626\u2010633.<\/jats:italic><\/jats:p>","DOI":"10.1902\/jop.2001.72.5.626","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T06:56:18Z","timestamp":1107327378000},"page":"626-633","source":"Crossref","is-referenced-by-count":11,"title":["Adhesion of <i>Porphyromonas gingivalis<\/i> Strains to Cultured Epithelial Cells From Patients With a History of Chronic Adult Periodontitis or From Patients Less Susceptible to Periodontitis"],"prefix":"10.1002","volume":"72","author":[{"given":"M.","family":"Quirynen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Papaioannou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.J.M.","family":"van Steenbergen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Dierickx","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.J.","family":"Cassiman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"van Steenberghe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,5]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2001.72.5.626","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:39:41Z","timestamp":1760873981000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2001.72.5.626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,5]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,5]]}},"alternative-id":["10.1902\/jop.2001.72.5.626"],"URL":"https:\/\/doi.org\/10.1902\/jop.2001.72.5.626","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"type":"print","value":"0022-3492"},{"type":"electronic","value":"1943-3670"}],"subject":[],"published":{"date-parts":[[2001,5]]}}}