{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:15:33Z","timestamp":1760919333359,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2001,7,1]],"date-time":"2001-07-01T00:00:00Z","timestamp":993945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2001,7]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The plasminogen activator system has been proposed to play a role in proteolytic degradation of extracellular matrices in tissue remodeling, including wound healing. The aim of this study was to elucidate the presence of components of the plasminogen activator system during different stages of periodontal wound healing.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Periodontal wounds were created around the molars of adult rats and healing was followed for 28 days. Immunohistochemical analyses of the healing tissues and an analysis of the periodontal wound healing fluid by ELISA were carried out for the detection of tissue\u2010type plasminogen activator (t\u2010PA), urokinase\u2010type plasminogen activator (u\u2010PA), and 2 plasminogen activator inhibitors (PAI\u20101 and PAI\u20102).<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> During the early stages (days 1 to 3) of periodontal wound healing, PAI\u20101 and PAI\u20102 were found to be closely associated with the deposition of a fibrin clot in the gingival sulcus. These components were strongly associated with the infiltrating inflammatory cells around the fibrin clot. During days 3 to 7, u\u2010PA, PAI\u20101, and PAI\u20102 were associated with cells (particularly monocytes\/macrophages, fibroblasts, and endothelial cells) in the newly formed granulation tissue. During days 7 to 14, a new attachment apparatus was formed during which PAI\u20101, PAI\u20102, and u\u2010PA were localized in both periodontal ligament fibroblasts (PDL) and epithelial cells at sites where these cells were attaching to the root surface. In the periodontal wound healing fluid, the concentration for t\u2010PA increased and peaked during the first week. PAI\u20102 had a similar expression to t\u2010PA, but at a lower level over the entire wound\u2010healing period.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> These findings indicate that the plasminogen activator system is involved in the entire process of periodontal wound healing, in particular with the formation of fibrin matrix on the root surface and its replacement by granulation tissue, as well as the subsequent formation of the attachment of soft tissue to the root surface during the later stages of wound repair. <jats:italic>J Periodontol 2001;72:849\u2010857.<\/jats:italic><\/jats:p>","DOI":"10.1902\/jop.2001.72.7.849","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T07:00:05Z","timestamp":1107327605000},"page":"849-857","source":"Crossref","is-referenced-by-count":22,"title":["The Expression of Plasminogen Activator System in a Rat Model of Periodontal Wound Healing"],"prefix":"10.1002","volume":"72","author":[{"given":"Yin","family":"Xiao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huika","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clive","family":"Bunn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. Mark","family":"Bartold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,7]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2001.72.7.849","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T08:34:20Z","timestamp":1760862860000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2001.72.7.849"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,7]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2001,7]]}},"alternative-id":["10.1902\/jop.2001.72.7.849"],"URL":"https:\/\/doi.org\/10.1902\/jop.2001.72.7.849","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"type":"print","value":"0022-3492"},{"type":"electronic","value":"1943-3670"}],"subject":[],"published":{"date-parts":[[2001,7]]}}}