{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:29:49Z","timestamp":1787023789397,"version":"build-2736575974"},"reference-count":0,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2001,7,1]],"date-time":"2001-07-01T00:00:00Z","timestamp":993945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2001,7]]},"abstract":"<jats:p>\n                    <jats:italic>\n                      <jats:bold>Background:<\/jats:bold>\n                      This is the first known case report that used a polymerase chain reaction (PCR)\u2010based method to help identify the oral microflora in patients with chronic neutropenia. In this study, we report clinical periodontal findings and microflora profiles of 2 children, 1 with severe congenital neutropenia (SCN, Kostmann type) and 1 with cyclic neutropenia (CN).\n                    <\/jats:italic>\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>\n                      <jats:bold>Methods:<\/jats:bold>\n                      The SCN patient had severe gingivitis, whereas the patient with CN had mild gingivitis in the gingival margins. Monthly oral cleaning instruction and review were performed without subsequent periodontal therapy. Oral hygiene conditions remained satisfactory and visible plaque was scarce, despite the persistence of mild gingivitis. Under supervised oral hygiene, we examined the presence of periodontal pathogens from patient plaque samples.\n                    <\/jats:italic>\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>\n                      <jats:bold>Results:<\/jats:bold>\n                      By a PCR\u2010based method,\n                    <\/jats:italic>\n                    Prevotella nigrescens, Bacteroides forsythus, Campylobacter rectus,\n                    <jats:italic>and<\/jats:italic>\n                    Capnocytophaga gingivalis\n                    <jats:italic>were detected in the SCN patient and<\/jats:italic>\n                    P. intermedia, C. rectus, C. gingivalis,\n                    <jats:italic>and<\/jats:italic>\n                    C. sputigena\n                    <jats:italic>in the CN patient, suggesting the existence of periodontal pathogens.<\/jats:italic>\n                    Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Treponema denticola,\n                    <jats:italic>and<\/jats:italic>\n                    C. ochracea\n                    <jats:italic>were not found in either patient.<\/jats:italic>\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>\n                      <jats:bold>Conclusions:<\/jats:bold>\n                      Use of 1% povidone iodine solution and local antibiotic application under supervised oral hygiene were helpful to improve gingival conditions in patients with chronic neutropenia.\n                    <\/jats:italic>\n                    J Periodontol 2001;72:945\u2010952.\n                  <\/jats:p>","DOI":"10.1902\/jop.2001.72.7.945","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T07:00:05Z","timestamp":1107327605000},"page":"945-952","source":"Crossref","is-referenced-by-count":19,"title":["Clinical Periodontal Findings and Microflora Profiles in Children With Chronic Neutropenia Under Supervised Oral Hygiene"],"prefix":"10.1002","volume":"72","author":[{"given":"Mitsugi","family":"Okada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takamune","family":"Hino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidemi","family":"Kurihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Miura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,7]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2001.72.7.945","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T08:34:19Z","timestamp":1760862859000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2001.72.7.945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,7]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2001,7]]}},"alternative-id":["10.1902\/jop.2001.72.7.945"],"URL":"https:\/\/doi.org\/10.1902\/jop.2001.72.7.945","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,7]]}}}