{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T09:24:15Z","timestamp":1778750655038,"version":"3.51.4"},"reference-count":0,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2001,8,1]],"date-time":"2001-08-01T00:00:00Z","timestamp":996624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Leukotriene B<jats:sub>4<\/jats:sub> (LTB<jats:sub>4<\/jats:sub>), a product of the lipoxygenase pathway of arachidonic acid metabolism, exhibits numerous activities that can account for most of the features of host responses seen in periodontal diseases. The aim of the present study was to examine the role of LTB<jats:sub>4<\/jats:sub> in the pathogenesis of specific periodontal diseases.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> LTB<jats:sub>4<\/jats:sub> levels were investigated in gingival crevicular fluid (GCF) and gingival tissue (GT) samples of 10 patients with chronic periodontitis (CP), 12 patients with generalized aggressive periodontitis (GAgP), 6 patients with localized aggressive periodontitis (LAgP), 6 patients with gingivitis (G), and 6 periodontally healthy subjects (H). Periodontal status was evaluated by measuring probing depth, gingival index, papillary bleeding index, and plaque index. LTB<jats:sub>4<\/jats:sub> was extracted from the samples by solid\u2010phase method using C<jats:sub>18<\/jats:sub> cartridge and was purified by high performance liquid chromatographic method and then analyzed by radioimmunoassay.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> All patient groups had significantly higher levels of GCF and GT LTB<jats:sub>4<\/jats:sub> compared to the control group (<jats:italic>P<\/jats:italic> &lt;0.005). The CP patients had the highest LTB<jats:sub>4<\/jats:sub> levels compared to those in other patient groups (<jats:italic>P<\/jats:italic> &lt;0.005). GAgP, LAgP, and G groups had similar amounts of GCF and GT LTB<jats:sub>4<\/jats:sub> (<jats:italic>P<\/jats:italic> &gt;0.005). When the data were expressed as concentration, the CP group was found to have higher concentration of LTB<jats:sub>4<\/jats:sub>, compared to that of control group (<jats:italic>P<\/jats:italic> &lt;0.005). GAgP, LAgP, and G groups had similar LTB<jats:sub>4<\/jats:sub> concentration compared to that of control group (<jats:italic>P<\/jats:italic> &gt;0.005). No significant difference was found between GAgP, LAgP, and G groups (<jats:italic>P<\/jats:italic> &gt;0.005). The CP group had higher LTB<jats:sub>4<\/jats:sub> concentration compared to both GAgP and LAgP groups (<jats:italic>P<\/jats:italic> &lt;0.005). Although the CP group had a higher GCF LTB<jats:sub>4<\/jats:sub> concentration compared to G group, this difference did not reach significance (<jats:italic>P<\/jats:italic> &gt;0.005). No significant correlation was found between GCF and GT LTB<jats:sub>4<\/jats:sub> levels and clinical parameters.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> The results of the present study indicate that LTB<jats:sub>4<\/jats:sub> is likely to be an important mediator in regulating inflammatory responses in the human periodontal tissues. This lipid mediator may play an important role in the pathophysiology of periodontal disease. <jats:italic>J Periodontol 2001;72:1025\u20101031.<\/jats:italic><\/jats:p>","DOI":"10.1902\/jop.2001.72.8.1025","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T07:00:21Z","timestamp":1107327621000},"page":"1025-1031","source":"Crossref","is-referenced-by-count":19,"title":["Levels of Leukotriene B<sub>4<\/sub> in Gingival Crevicular Fluid and Gingival Tissue in Specific Periodontal Diseases"],"prefix":"10.1002","volume":"72","author":[{"given":"G\u00fclnur","family":"Emingil","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serhat","family":"\u00c7inarcik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haluk","family":"Baylas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I\u015fil","family":"\u00c7oker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afig","family":"H\u00fcseyinov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,8]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2001.72.8.1025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T13:38:38Z","timestamp":1760881118000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2001.72.8.1025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,8]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2001,8]]}},"alternative-id":["10.1902\/jop.2001.72.8.1025"],"URL":"https:\/\/doi.org\/10.1902\/jop.2001.72.8.1025","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,8]]}}}