{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:15:09Z","timestamp":1784542509666,"version":"3.55.0"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The purpose of the present study was to assess the effects of adjunctive meloxicam on the matrix metalloproteinase\u20108 (MMP\u20108) levels of gingival crevicular fluid (GCF) in chronic periodontitis patients following the initial phase of periodontal therapy.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Twelve chronic periodontitis patients received 7.5 mg meloxicam, and 10 patients received placebo tablets together with scaling and root planing in a 1 \u00d7 1 regimen for 10 days. Scaling and root planing were performed on day 3 of drug intake. The MMP\u20108 levels in GCF samples obtained before and on day 10 of drug intake were determined by using the immunofluorescence assay. Plaque index (PI), papilla bleeding index (PBI), and GCF MMP\u20108 levels were compared within each patient group, between the 2 patient groups, and also with a clinically healthy control group using non\u2010parametric statistical analyses.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Both meloxicam and placebo groups showed statistically significant reductions in PBI, PI, and GCF MMP\u20108 levels on day 10 compared to baseline (<jats:italic>P<\/jats:italic> &lt;0.01). The GCF MMP\u20108 level on day 10 in the meloxicam group was similar to the clinically healthy control group (<jats:italic>P<\/jats:italic> &gt;0.05), while it was significantly higher in the placebo group (<jats:italic>P<\/jats:italic> &lt;0.01). Positive correlations were found between MMP\u20108 total amounts and PBI scores at baseline and day 10 of drug intake in the patient groups.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Meloxicam showed a tendency to reduce GCF MMP\u20108 levels in vivo within the first 10 days when used as an adjunct in the initial phase of periodontal treatment that consists of scaling and root planing. Verification of this effect on collagenase\u20102 downregulation, as well as on the clinical periodontal parameters in long\u2010term studies using larger test and control groups, is needed to provide further support for the adjunctive use of selective cyclooxygenase (COX)\u20102 inhibitors in the treatment of chronic periodontitis. <jats:italic>J Periodontol 2002;73:103\u2010109.<\/jats:italic><\/jats:p>","DOI":"10.1902\/jop.2002.73.1.103","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T07:05:08Z","timestamp":1107327908000},"page":"103-109","source":"Crossref","is-referenced-by-count":41,"title":["Gingival Crevicular Fluid Matrix Metalloproteinase\u20108 Levels Following Adjunctive Use of Meloxicam and Initial Phase of Periodontal Therapy"],"prefix":"10.1002","volume":"73","author":[{"given":"Nurcan","family":"Buduneli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saynur","family":"Vardar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcl","family":"Atilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Sorsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne","family":"Luoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haluk","family":"Baylas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,1]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2002.73.1.103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T14:37:05Z","timestamp":1760884625000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2002.73.1.103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["10.1902\/jop.2002.73.1.103"],"URL":"https:\/\/doi.org\/10.1902\/jop.2002.73.1.103","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1]]}}}