{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T14:32:30Z","timestamp":1768833150315,"version":"3.49.0"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:p><jats:italic><jats:bold>Background:<\/jats:bold> Long\u2010term evaluation of periodontal therapy is important for clinical decision making.<\/jats:italic><\/jats:p><jats:p><jats:italic><jats:bold>Methods:<\/jats:bold> A synthetic cell\u2010binding peptide (P\u201015) combined with anorganic bovine\u2010derived hydroxyapatite bone matrix (ABM) was evaluated as a bone replacement graft in human periodontal osseous defects. Following initial preparation and reevaluation, flap surgery was performed. A variety of 1\u2010, 2\u2010, 3\u2010wall bony defects were curetted and root surfaces subjected to mechanical debridement only. The bone defects were grafted with ABM\/P\u201015, and the host flaps replaced or slightly coronally positioned. Weekly, then monthly deplaquing was performed until surgical reentry at 6 to 7 months. Patients were then followed on approximate 3\u2010month recalls for 3 years. Twenty\u2010five of the original 31 patients qualified for long\u2010term evaluation in that their ABM\/P\u201015 treated sites did not receive any additional therapy at the time of reentry.<\/jats:italic><\/jats:p><jats:p><jats:italic><jats:bold>Results:<\/jats:bold> Significant clinical changes for the overall group of bony defects included improvement in mean clinical attachment level from 5.4 mm at surgery to 4.5 mm at the 6\u2010month reentry to 3.8 mm at 3 years. There was also a decrease in mean probing depth from 5.3 mm at surgery to 3.1 mm at the 6\u2010month reentry to 2.9 mm at 3 years. The mean gingival recession changed from +0.1 mm at surgery to 1.4 mm at the 6\u2010month reentry to 0.9 mm at 3 years. All of these differences were at least P &lt;0.05 from surgery to the 6\u2010month reentry, and surgery to 3 years, but were not significant from reentry to 3 years via repeated measures analysis of variance.<\/jats:italic><\/jats:p><jats:p><jats:italic><jats:bold>Conclusions:<\/jats:bold> These favorable 3\u2010year results with ABM\/P\u201015 suggest that it may have a beneficial effect in the long\u2010term clinical management of infrabony defects. Further long\u2010term randomized controlled studies are needed to better assess the role of ABM\/P\u201015 in long\u2010term healing of periodontal osseous defects.<\/jats:italic> J Periodontol 2002;73:123\u2010128.<\/jats:p>","DOI":"10.1902\/jop.2002.73.1.123","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T07:05:08Z","timestamp":1107327908000},"page":"123-128","source":"Crossref","is-referenced-by-count":53,"title":["Thirty\u2010Six Month Follow\u2010up of 25 Patients Treated With Combination Anorganic Bovine\u2010Derived Hydroxyapatite Matrix (ABM)\/Cell\u2010Binding Peptide (P\u201015) Bone Replacement Grafts in Human Infrabony Defects. I. Clinical Findings"],"prefix":"10.1002","volume":"73","author":[{"given":"Raymond A.","family":"Yukna","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack T.","family":"Krauser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald P.","family":"Callan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald H.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renee","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Millicent","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,1]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2002.73.1.123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T14:37:05Z","timestamp":1760884625000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2002.73.1.123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["10.1902\/jop.2002.73.1.123"],"URL":"https:\/\/doi.org\/10.1902\/jop.2002.73.1.123","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1]]}}}