{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:21:38Z","timestamp":1791426098036,"version":"4.3.3"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Recombinant human bone morphogenetic protein\u20102 (rhBMP\u20102) in an absorbable collagen sponge (ACS) carrier is being evaluated as a candidate therapy for periodontal regeneration. The objective of this study was to evaluate regeneration of alveolar bone and cementum, and associated root resorption and ankylosis following surgical implantation of rhBMP\u20102\/ACS in a canine clinical model.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Bilateral 3\u2010wall intrabony periodontal defects were surgically induced in the premolar region in the maxilla and mandible in 8 young adult Korean mongrel dogs. The defects in each animal received rhBMP\u20102\/ACS (rhBMP\u20102 at 0.2 mg\/ml, total implant volume\/defect ~ 0.1 ml) or buffer\/ACS, or served as sham\u2010operated controls. Surgeries were sequenced for each animal to provide postmortem observations following 8\u2010 and 24\u2010week healing intervals. Treatment outcomes were evaluated using clinical, radiographic, and histometric parameters.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Surgical implantation of rhBMP\u20102\/ACS resulted in accelerated enhanced bone formation in the 3\u2010wall intrabony periodontal defects but in no apparent enhancement of cementum regeneration. rhBMP\u20102\/ACS did not appear to be associated with aberrant healing events such as root resorption and ankylosis under these simulated clinical conditions.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Surgical implantation of rhBMP\u20102\/ACS may be used safely to support regeneration of alveolar bone in intrabony periodontal defects in dogs without aberrant events such as root resorption or ankylosis complicating the regenerative procedure. rhBMP\u20102\/ACS does not appear to have a significant effect on cementum regeneration and formation of a functional periodontal ligament in this model.\n                    <jats:italic>J Periodontol 2002;73:63\u201072.<\/jats:italic>\n                  <\/jats:p>","DOI":"10.1902\/jop.2002.73.1.63","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T07:05:08Z","timestamp":1107327908000},"page":"63-72","source":"Crossref","is-referenced-by-count":137,"title":["Effect of Recombinant Human Bone Morphogenetic Protein\u20102\/Absorbable Collagen Sponge (rhBMP\u20102\/ACS) on Healing in 3\u2010Wall Intrabony Defects in Dogs"],"prefix":"10.1002","volume":"73","author":[{"given":"Seong\u2010Ho","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong\u2010Kwan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoo\u2010Sung","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Sun","family":"Huh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel G.","family":"Sorensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Wozney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf M.E.","family":"Wikesj\u00f6","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,1]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2002.73.1.63","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T14:37:08Z","timestamp":1760884628000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2002.73.1.63"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["10.1902\/jop.2002.73.1.63"],"URL":"https:\/\/doi.org\/10.1902\/jop.2002.73.1.63","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1]]}}}