{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:20:54Z","timestamp":1791426054014,"version":"4.3.3"},"reference-count":0,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2002,12,1]],"date-time":"2002-12-01T00:00:00Z","timestamp":1038700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Recombinant human bone morphogenetic protein\u20102 (rhBMP\u20102) in a proper carrier has been shown to induce clinically relevant bone formation for several oral\/maxillofacial and periodontal indications and to stimulate regeneration of the periodontal attachment. The objective of this study is to evaluate regeneration of alveolar bone, cementum, periodontal ligament, and associated root resorption and ankylosis following surgical implantation of rhBMP\u20102 in an absorbable collagen sponge (ACS) or a calcium phosphate putty (\u03b1BSM) carrier in 3\u2010wall intrabony periodontal defects in the baboon.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> rhBMP\u20102\/ACS and rhBMP\u20102\/\u03b1BSM were implanted in surgically produced, maxillary and mandibular, large size, 3\u2010wall intrabony defects in 4 baboons. Contralateral jaw quadrants were implanted with buffer\/ACS, buffer\/ \u03b1BSM, or served as sham\u2010operated surgical controls. Treatments were allocated to left and right, maxillary and mandibular, jaw quadrants following a randomization schedule. Four months following implantation, block biopsies of defect sites were obtained, processed, and subjected to histologic and histometric analysis.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Defect sites receiving rhBMP\u20102\/ACS and rhBMP\u20102\/\u03b1BSM demonstrated significantly greater regeneration than controls. No significant differences were observed between defect sites receiving rhBMP\u20102\/ACS or rhBMP\u20102\/\u03b1BSM regarding epithelial migration and connective tissue attachment and new bone formation. However, rhBMP\u20102\/ACS supported signifi\u2010cantly greater new cementum formation. Ankylosis or root resorption were not observed.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> The results of this study support the use of rhBMP\u20102 to enhance periodontal regeneration of intrabony periodontal defects. While this novel technology holds promise, refinement in carrier systems may provide the key to enhancement of the regenerative potential. <jats:italic>J Periodontol 2002;73:1494\u20101506.<\/jats:italic><\/jats:p>","DOI":"10.1902\/jop.2002.73.12.1494","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T07:16:15Z","timestamp":1107328575000},"page":"1494-1506","source":"Crossref","is-referenced-by-count":47,"title":["Effect of Surgical Implantation of Recombinant Human Bone Morphogenetic Protein\u20102 in a Bioabsorbable Collagen Sponge or Calcium Phosphate Putty Carrier in Intrabony Periodontal Defects in the Baboon"],"prefix":"10.1002","volume":"73","author":[{"given":"Neil M.","family":"Blumenthal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Koh\u2010Kunst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario E.A.F.","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel G.","family":"Sorensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Wozney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf M.E.","family":"Wikesj\u00f6","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,12]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2002.73.12.1494","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:46:59Z","timestamp":1760870819000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2002.73.12.1494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,12]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2002,12]]}},"alternative-id":["10.1902\/jop.2002.73.12.1494"],"URL":"https:\/\/doi.org\/10.1902\/jop.2002.73.12.1494","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,12]]}}}