{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:30:01Z","timestamp":1760920201157,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2002,12,1]],"date-time":"2002-12-01T00:00:00Z","timestamp":1038700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> It has been suggested that locally produced immunoglobulin (Ig)A could be more protective than IgG and that there could be a relationship between crevicular fluid\u2010specific IgA levels and the onset of periodontal disease. This study was designed to investigate this hypothesis regarding specific immune responses towards 4 plaque anaerobes in gingival crevicular fluid and saliva from patients with periodontopathies and controls.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Gingival crevicular fluid (GCF) and whole saliva were collected from 35 adults with periodontitis and 24 periodontally healthy adults (controls). Antigens were extracted from <jats:italic>Actinomyces actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia,<\/jats:italic> and <jats:italic>Fusobacterium nucleatum<\/jats:italic> and used to set up specific enzyme\u2010linked immunosorbent assay (ELISA) tests to assess IgA and IgG levels to these microorganisms in the fluids collected.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The crevicular fluid of periodontitis patients contained significantly higher levels of IgG to the 4 microorganisms tested than that of controls (<jats:italic>P<\/jats:italic> &lt;10<jats:sup>\u20136<\/jats:sup> for all comparisons). IgA levels to the 4 bacteria were statistically significantly much higher in control crevicular fluid (<jats:italic>P<\/jats:italic> &lt;10<jats:sup>\u20137<\/jats:sup> for all comparisons). Controls also had statistically significantly higher levels of specific salivary IgA than patients (<jats:italic>P<\/jats:italic> &lt;0.02 for all comparisons).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> These data support the potentially protective role of specific IgA directed to oral microorganisms involved in the onset and development of periodontal disease. <jats:italic>J Periodontol 2002;73:1507\u20101511.<\/jats:italic><\/jats:p>","DOI":"10.1902\/jop.2002.73.12.1507","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T07:16:15Z","timestamp":1107328575000},"page":"1507-1511","source":"Crossref","is-referenced-by-count":17,"title":["Isotypic Antibody Response to Plaque Anaerobes in Periodontal Disease"],"prefix":"10.1002","volume":"73","author":[{"given":"Marc","family":"Plombas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Gobert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Kennel","family":"De March","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie N. Kolopp","family":"Sarda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Sixou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie C.","family":"B\u00e9n\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neal","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilbert C.","family":"Faure","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,12]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2002.73.12.1507","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:46:56Z","timestamp":1760870816000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2002.73.12.1507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,12]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2002,12]]}},"alternative-id":["10.1902\/jop.2002.73.12.1507"],"URL":"https:\/\/doi.org\/10.1902\/jop.2002.73.12.1507","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"type":"print","value":"0022-3492"},{"type":"electronic","value":"1943-3670"}],"subject":[],"published":{"date-parts":[[2002,12]]}}}