{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:29:11Z","timestamp":1760920151056,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,4,1]],"date-time":"2002-04-01T00:00:00Z","timestamp":1017619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2002,4]]},"abstract":"<jats:p><jats:italic><jats:bold>Background:<\/jats:bold> The aim of this 5\u2010year follow\u2010up case series was to clinically and radiographically evaluate the long\u2010term results after guided tissue regeneration (GTR) therapy of infrabony defects using nonresorbable and bioabsorbable barriers.<\/jats:italic><\/jats:p><jats:p><jats:italic><jats:bold>Methods:<\/jats:bold> In 12 patients with advanced chronic periodontitis 12 pairs of contralateral infrabony defects were treated. Within each patient one defect received a non\u2010resorbable (expanded polytetrafluoroethylene [ePTFE]; control: C) and the other a bioabsorbable (polyglactin 910; test: T) barrier by random assignment. At baseline and at 6 and 60 \u00b13 months after surgery clinical parameters and standardized radiographs were obtained. Gain of bone density within infrabony defects was assessed using subtraction radiography.<\/jats:italic><\/jats:p><jats:p><jats:italic><jats:bold>Results:<\/jats:bold> Eight of 12 patients were available for the 60\u2010month reexaminations. Six and 60 \u00b13 months after GTR therapy statistically significant (P &lt;0.05) vertical attachment (CAL\u2010V) gain was observed in both groups (C6: 2.6 \u00b11.4 mm; C60: 1.6 \u00b1 1.5 mm; T6: 3.0 \u00b11.7 mm; T60: 3.0 \u00b10.7 mm). However at 60 months, 2 infrabony defects in the control group had lost all the attachment that had been gained 6 months after therapy and a clinically relevant but statistically insignificant mean CAL\u2010V loss of 1.0 \u00b12.1 mm was observed from 6 to 60 months. The case series failed to show statistically significant differences between test and control regarding CAL\u2010V gain 60 months after surgery. Also subtraction analysis failed to reveal statistically significant differences regarding density gain between both groups 6 and 60 months postsurgically (C6: 26.4 \u00b1 54.2; C60 62.8 \u00b1112.7; T6: 68.7 \u00b172.8; T60. 84.1 \u00b183.6).<\/jats:italic><\/jats:p><jats:p><jats:italic><jats:bold>Conclusions:<\/jats:bold> CAL\u2010V gain achieved after GTR therapy in infrabony defects using both non\u2010resorbable and bioabsorbable barriers was quite stable after 5 years in 14 of 16 defects.<\/jats:italic> J Periodontol 2002;73:450\u2010459.<\/jats:p>","DOI":"10.1902\/jop.2002.73.4.450","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T07:22:14Z","timestamp":1107328934000},"page":"450-459","source":"Crossref","is-referenced-by-count":34,"title":["Long\u2010Term Results of Guided Tissue Regeneration Therapy With Non\u2010Resorbable and Bioabsorbable Barriers. II. A Case Series of Infrabony Defects"],"prefix":"10.1002","volume":"73","author":[{"given":"Ti\u2010Sun","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf","family":"Holle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernest","family":"Hausmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Eickholz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,4]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2002.73.4.450","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:41:26Z","timestamp":1760870486000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2002.73.4.450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,4]]}},"alternative-id":["10.1902\/jop.2002.73.4.450"],"URL":"https:\/\/doi.org\/10.1902\/jop.2002.73.4.450","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"type":"print","value":"0022-3492"},{"type":"electronic","value":"1943-3670"}],"subject":[],"published":{"date-parts":[[2002,4]]}}}