{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T22:26:19Z","timestamp":1789943179373,"version":"4.0.1"},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2002,5,1]],"date-time":"2002-05-01T00:00:00Z","timestamp":1020211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Matrix metalloproteinase\u20101 (MMP\u20101) is a member of a family of enzymes which are capable of degrading most extracellular matrix macromolecules. Extracellular control of MMPs is exerted by tissue inhibitors of metalloproteinases (TIMP) and by mechanisms of pro\u2010MMP activation. Levels of MMPs and TIMPs change during healing, inflammation, and normal tissue turnover. The aim of this study was to evaluate the effects of phase I periodontal treatment on gingival crevicular fluid (GCF) levels of MMP\u20101 and TIMP\u20101.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Ten patients with chronic periodontitis who had sites with probing depths \u22654 mm and 10 periodontally healthy persons (controls) were included in this study. Clinical measurements including plaque (PI) and gingival (GI) indexes, probing depths (PD), and clinical attachment loss (CAL) were recorded both at baseline (before treatment, BT) and after phase I periodontal treatment (AT). Assays for MMP\u20101 and TIMP\u20101 were performed by an enzyme\u2010linked immunosorbent assay (ELISA) method.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    All of the clinical conditions significantly improved and GCF volume decreased AT (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05). Levels of MMP\u20101 were higher in patients BT than in controls (C) (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05). Levels of MMP\u20101 were reduced AT compared to BT (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05). In addition, TIMP\u20101 levels were lower at BT than AT and in C (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05). Statistically significant differences were found between levels of TIMP\u20101 at BT and AT (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05). The ratio of MMP\u20101 to TIMP\u20101 was significantly lower in C than patients at BT; this ratio was also significantly lower at AT than BT (P &lt;0.05).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    These results suggest that levels of MMP\u20101 in GCF decreased and total levels of TIMP\u20101 in GCF increased after phase I periodontal therapy. The ratio of MMP\u20101 to TIMP\u20101 changed after phase I periodontal therapy, becoming close to that of the controls.\n                    <jats:italic>J Periodontol 2002;73:487\u2010493.<\/jats:italic>\n                  <\/jats:p>","DOI":"10.1902\/jop.2002.73.5.487","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T06:17:34Z","timestamp":1107325054000},"page":"487-493","source":"Crossref","is-referenced-by-count":56,"title":["Effects of Phase I Periodontal Treatment on Gingival Crevicular Fluid Levels of Matrix Metalloproteinase\u20101 and Tissue Inhibitor of Metalloproteinase\u20101"],"prefix":"10.1002","volume":"73","author":[{"given":"G\u00fclay","family":"T\u00fcter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00fclent","family":"Kurti\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhittin","family":"Serdar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,5]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2002.73.5.487","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:40:59Z","timestamp":1760874059000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2002.73.5.487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,5]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,5]]}},"alternative-id":["10.1902\/jop.2002.73.5.487"],"URL":"https:\/\/doi.org\/10.1902\/jop.2002.73.5.487","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,5]]}}}