{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T14:38:48Z","timestamp":1770475128347,"version":"3.49.0"},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2002,5,1]],"date-time":"2002-05-01T00:00:00Z","timestamp":1020211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The present study evaluated the healing of enamel matrix derivative (EMD) proteins in the treatment of periodontal lesions with deep intrabony defects.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Ten deep intrabony defects in 7 periodontal patients were treated and followed for 1 year. The sites had a probing depth (PD) \u22658 mm; clinical attachment level (CAL) \u22659 mm, and intrabony component depth \u22655 mm. All subjects received therapy prior to surgery and had a plaque score (PI) \u226410%. Full thickness flaps were elevated buccally and lingually, granulation tissue was removed from the defects, and the root surfaces were planed. A 24% EDTA gel was applied followed by the enamel matrix protein preparation. The flaps were closed with interrupted sutures. The patients rinsed with a chlorhexidine solution twice a day for 6 weeks. They were recalled every 2 weeks for 6 months for professional tooth cleaning and then every 4 weeks for an additional 6 months. The experimental sites were reexamined 6 and 12 months after regenerative surgery.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> At the 1\u2010year examination, the mean CAL gain was 6.5 mm, the mean PD was 3.2 mm, and mean radiographic bone fill was 4.7 mm.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> The application of enamel matrix proteins in combination with open flap curettage and root planing resulted in a gain of CAL and bone fill in deep intrabony defects. <jats:italic>J Periodontol 2002;73:501\u2010504.<\/jats:italic><\/jats:p>","DOI":"10.1902\/jop.2002.73.5.501","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T06:17:34Z","timestamp":1107325054000},"page":"501-504","source":"Crossref","is-referenced-by-count":25,"title":["Enamel Matrix Proteins in the Treatment of Deep Intrabony Defects"],"prefix":"10.1002","volume":"73","author":[{"given":"Giuseppe","family":"Cardaropoli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c5sa S.","family":"Leonhardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,5]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2002.73.5.501","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:40:59Z","timestamp":1760874059000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2002.73.5.501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,5]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,5]]}},"alternative-id":["10.1902\/jop.2002.73.5.501"],"URL":"https:\/\/doi.org\/10.1902\/jop.2002.73.5.501","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,5]]}}}