{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:48:00Z","timestamp":1777589280123,"version":"3.51.4"},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2002,5,1]],"date-time":"2002-05-01T00:00:00Z","timestamp":1020211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Receptors for the Fc fragment of immunoglobulin G (Fc\u03b3Rs) play a crucial role in host defense against bacterial infection by linking humoral and cell\u2010mediated immune responses. Allelic variants of certain Fc\u03b3Rs have been shown to differ relative to their biologic activity. Thus, genes encoding allotypes with diminished activity have been suggested as potential risk factors for infectious diseases. The goal of this study was to determine whether specific Fc\u03b3RIIa, Fc\u03b3RIIIa, and Fc\u03b3RIIIb alleles and\/or genotypes could be used to predict susceptibility to localized aggressive periodontitis (LAgP) in an African\u2010American population.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Whole blood or saliva was obtained from 48 LAgP and 67 periodontally\u2010healthy African\u2010American subjects. DNA was prepared from each sample. Fc\u03b3RIIa and Fc\u03b3RIIIa genotyping was analyzed by polymerase chain reaction (PCR) amplification of DNA with allele\u2010specific primers followed by allelespecific restriction digestion of the products. Fc\u03b3RIIIb genotyping was done by allele\u2010specific PCR.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> There was a statistically significant over\u2010representation of the Fc\u03b3RIIIb\u2010NA2 allele in LAgP patients compared to controls (<jats:italic>P<\/jats:italic> = 0.024). Relative to the Fc\u03b3RIIIb\u2010NA1\/NA2 and homozygous NA1\/NA1 genotypes, the prevalence of the Fc\u03b3RIIIb NA2\/NA2 genotype was higher in the LAgP group relative to the control population. Individuals expressing this genotype appeared at greater risk for developing LAgP (odds ratio 2.271, 95% confidence interval: 1.005 to 5.132). There were no significant differences in the distribution of the Fc\u03b3RIIa H\/R or Fc\u03b3RIIIa\u2010158 F\/V genotypes nor their allelic frequencies between the LAgPpatients and controls.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> These data suggest that the Fc\u03b3RIIIb NA2 allele and\/or NA2\/NA2 genotype may represent risk markers for susceptibility to LAgP in African\u2010Americans. <jats:italic>J Periodontol 2002;73:517\u2010523.<\/jats:italic><\/jats:p>","DOI":"10.1902\/jop.2002.73.5.517","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T06:17:34Z","timestamp":1107325054000},"page":"517-523","source":"Crossref","is-referenced-by-count":38,"title":["Fc\u03b3 Receptor Genes as Risk Markers for Localized Aggressive Periodontitis in African\u2010Americans"],"prefix":"10.1002","volume":"73","author":[{"given":"Yali","family":"Fu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan M.","family":"Korostoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel H.","family":"Fine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark E.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,5]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2002.73.5.517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:40:58Z","timestamp":1760874058000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2002.73.5.517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,5]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,5]]}},"alternative-id":["10.1902\/jop.2002.73.5.517"],"URL":"https:\/\/doi.org\/10.1902\/jop.2002.73.5.517","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,5]]}}}