{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:15:11Z","timestamp":1784542511177,"version":"3.55.0"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The purpose of the present study was to evaluate the effect of a relatively selective cyclooxygenase (COX)\u20102 inhibitor (nimesulide) and non\u2010selective COX\u20101\/COX\u20102 inhibitor (naproxen) used as an adjunct to non\u2010surgical (scaling and root planing [SRP]) periodontal therapy in chronic periodontitis patients on the gingival tissue (GT) levels of prostaglandin (PG)E<jats:sub>2<\/jats:sub> and PGF<jats:sub>2\u03b1<\/jats:sub>.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Thirty patients with chronic periodontitis were divided into 3 groups of 10 each. One group received 100 mg of nimesulide; one received 275 mg of naproxen sodium; and the third group received placebo tablets in a 2 \u00d7 1 regimen for 10 days as an adjunct to SRP. GT samples were obtained before drug intake and on day 10. Plaque index (PI) and papillary bleeding index (PBI) scores were recorded at baseline, day 10, and at 3 months; probing depth (PD) and clinical attachment level (CAL) were recorded at baseline and at 3 months. The levels of PGE<jats:sub>2<\/jats:sub> were detected using an enzyme immunoassay (EIA), and the levels of PGF<jats:sub>2\u03b1<\/jats:sub> were analyzed by radioimmunoassay (RIA). Differences among and within the groups were assessed using non\u2010parametric statistical analysis. Ten periodontally healthy individuals served as controls.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> All 3 groups showed statistically significant reductions in PBI and PI on day 10 and at 3 months (<jats:italic>P<\/jats:italic>&lt;0.02), and in PD and CAL at 3 months (<jats:italic>P<\/jats:italic>&lt;0.02, <jats:italic>P<\/jats:italic>&lt;0.05, respectively). In the naproxen group, GT PGE<jats:sub>2<\/jats:sub> levels exhibited a significant decrease (<jats:italic>P<\/jats:italic>&lt;0.05). However, the decrease of GT PGE<jats:sub>2<\/jats:sub> levels in the nimesulide group was insignificant (<jats:italic>P<\/jats:italic>&gt;0.05), while a significant increase was observed in the placebo group (<jats:italic>P<\/jats:italic>&lt;0.05) on day 10. Both the nimesulide and naproxen groups showed a significant decrease (<jats:italic>P<\/jats:italic>&lt;0.05) in PGF<jats:sub>2\u03b1<\/jats:sub> level, while the placebo group showed a significant increase (<jats:italic>P<\/jats:italic>&lt;0.05).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Nimesulides, relatively selective COX\u20102 inhibitors, may have additional inhibitory effects on GT PGF<jats:sub>2\u03b1<\/jats:sub> levels in the first week following non\u2010surgical periodontal treatment. However, nimesulide has an insignificant effect on reducing PGE<jats:sub>2<\/jats:sub> levels in gingival tissue. The determination of GT levels of COX\u20101 and COX\u20102 enzymes as well as PGE<jats:sub>2<\/jats:sub> and PGF<jats:sub>2\u03b1<\/jats:sub> in long\u2010term studies may provide further support for the adjunctive use of selective COX\u20102 inhibitors in treatment of chronic periodontitis. <jats:italic>J Periodontol 2003;74:57\u201063.<\/jats:italic><\/jats:p>","DOI":"10.1902\/jop.2003.74.1.57","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T07:31:16Z","timestamp":1107329476000},"page":"57-63","source":"Crossref","is-referenced-by-count":36,"title":["Effects of Selective Cyclooxygenase\u20102 Inhibition on Gingival Tissue Levels of Prostaglandin E<sub>2<\/sub> and Prostaglandin F<sub>2\u03b1<\/sub> and Clinical Parameters of Chronic Periodontitis"],"prefix":"10.1002","volume":"74","author":[{"given":"Saynur","family":"Vardar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haluk","family":"Baylas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afig","family":"Huseyinov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,1]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2003.74.1.57","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:24:36Z","timestamp":1760869476000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2003.74.1.57"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,1]]}},"alternative-id":["10.1902\/jop.2003.74.1.57"],"URL":"https:\/\/doi.org\/10.1902\/jop.2003.74.1.57","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,1]]}}}