{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:43:30Z","timestamp":1787669010090,"version":"build-2736575974"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,2,1]],"date-time":"2003-02-01T00:00:00Z","timestamp":1044057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2003,2]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The aim of the present study was to compare the effectiveness of Nd:YAG and CO<jats:sub>2<\/jats:sub> laser treatment to that of ultrasonic scaling used as monotherapies by examining clinical parameters, subgingival microflora, and interleukin\u20101 beta (IL\u20101\u03b2) in gingival crevicular fluid (GCF).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Eighteen patients, each of whom had 2 or more sites with probing depth measuring &gt;5 mm, were included this clinical trial. The 41 sites were randomly assigned treatment with either Nd:YAG laser alone (n = 14, 100 mj, 20 pps, 2.0 W, 120 seconds), CO<jats:sub>2<\/jats:sub> laser alone (n = 13, 2.0 W, 120 seconds), or ultrasonic scaling alone (n = 14, maximum power, 120 seconds). At baseline and at 1, 4, and 12 weeks, clinical measurements (plaque index, PI; gingival index, GI; probing depth, PD; clinical attachment level, CAL; and bleeding on probing, BOP) were performed and subgingival plaque and GCF sampled. A quantitative analysis of <jats:italic>Porphyromonas gingivalis<\/jats:italic> was carried out using real\u2010time polymerase chain reaction (PCR) procedures. The amounts of IL\u20101\u03b2 were estimated by an enzyme\u2010linked immunosorbent assay (ELISA).<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Decreased inflammation and PD were observed in all 3 groups after treatment. A microbiological analysis indicated significant decreases in <jats:italic>P. gingivalis<\/jats:italic> in the Nd:YAG and scaling groups at 1, 4, and 12 weeks compared to baseline (<jats:italic>P<\/jats:italic> &lt;0.05). The amount of GCF significantly decreased in the Nd:YAG and scaling groups at 12 weeks. The amount of IL\u20101\u03b2 increased in the CO<jats:sub>2<\/jats:sub> group from baseline to 1 week (<jats:italic>P<\/jats:italic> &lt;0.05). The Nd:YAG group tended to show a decrease in IL\u20101\u03b2 from 1 to 12 weeks, although these data were not statistically significant.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Our data suggest that Nd:YAG laser and ultrasonic scaling treatments showed significant improvements regarding the clinical parameters and subgingival microflora compared to the baseline, but no significant difference was observed between the 3 groups. <jats:italic>J Periodontol 2003;74:175\u2010180.<\/jats:italic><\/jats:p>","DOI":"10.1902\/jop.2003.74.2.175","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T07:35:22Z","timestamp":1107329722000},"page":"175-180","source":"Crossref","is-referenced-by-count":69,"title":["Effects of Nd:YAG and CO<sub>2<\/sub> Laser Treatment and Ultrasonic Scaling on Periodontal Pockets of Chronic Periodontitis Patients"],"prefix":"10.1002","volume":"74","author":[{"given":"Akira","family":"Miyazaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshikazu","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Nishikata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Okuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Suda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuko","family":"Orima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhisa","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromasa","family":"Yoshie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,2]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2003.74.2.175","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:16:31Z","timestamp":1760872591000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2003.74.2.175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,2]]}},"alternative-id":["10.1902\/jop.2003.74.2.175"],"URL":"https:\/\/doi.org\/10.1902\/jop.2003.74.2.175","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,2]]}}}