{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:17:41Z","timestamp":1760919461712,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2003,4]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Apoptosis plays an important role in the maintenance of tissue homeostasis. Considering that apoptosis mediators may play a role in the pathogenesis of drug\u2010induced gingival overgrowth, this study was conducted to evaluate p53, bcl\u20102, and interleukin\u201015 (IL\u201015) levels in gingival crevicular fluid (GCF) of cyclosporin A (CsA)\u2010treated patients.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Twenty renal transplant patients exhibiting CsA\u2010induced gingival overgrowth and 15 systemically healthy gingivitis patients were included in the study; 15 systemically and periodontally healthy volunteer subjects served as the healthy control group. GCF samples were obtained from one interdental site with gingival overgrowth (GO+) and one site without (GO\u2013) from each CsA\u2010treated patient; hyperplasia index, probing depth, papilla bleeding index, and plaque presence were recorded. One site from each gingivitis patient and healthy control was selected, GCF samples were obtained, and the same clinical parameters were recorded. GCF p53, bcl\u20102, and IL\u201015 levels were analyzed by enzyme\u2010linked immunosorbent assay. The results were tested statistically.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> p53 and bcl\u20102 levels were below the minimum detectable level in all GCF samples analyzed. CsA GO+ and CsA GO\u2013 sites, as well as gingivitis sites, exhibited significantly higher GCF levels of IL\u201015 compared to healthy controls (<jats:italic>P<\/jats:italic> &lt;0.05). The difference between CsA GO+ sites and gingivitis sites was not statistically significant, although the total amount of IL\u201015 in CsA GO+ sites was lower than gingivitis sites (<jats:italic>P<\/jats:italic> &gt;0.05). The total amount of IL\u201015 in CsA GO\u2013 sites was significantly lower than gingivitis sites (<jats:italic>P<\/jats:italic> &lt;0.05). No significant correlation was found between the clinical parameters and GCF IL\u201015 levels (<jats:italic>P<\/jats:italic>&gt;0.05).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> The pathogenesis of CsA\u2010induced gingival overgrowth is multifactorial. The findings of the present study indicate that IL\u201015 may play a role in the pathogenesis of CsA\u2010induced gingival overgrowth due to its interactions with CsA and its role in apoptosis and inflammation. <jats:italic>J Periodontol 2003;74:506\u2010511<\/jats:italic><\/jats:p>","DOI":"10.1902\/jop.2003.74.4.506","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T07:38:16Z","timestamp":1107329896000},"page":"506-511","source":"Crossref","is-referenced-by-count":11,"title":["Evaluation of p53, bcl\u20102, and Interleukin\u201015 Levels in Gingival Crevicular Fluid of Cyclosporin A\u2010Treated Patients"],"prefix":"10.1002","volume":"74","author":[{"given":"Eralp","family":"Buduneli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferah","family":"Genel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcl","family":"Atilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Necil","family":"K\u00fct\u00fck\u00e7\u00fc\u00e7ler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,4]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2003.74.4.506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T08:41:12Z","timestamp":1760863272000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2003.74.4.506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,4]]}},"alternative-id":["10.1902\/jop.2003.74.4.506"],"URL":"https:\/\/doi.org\/10.1902\/jop.2003.74.4.506","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"type":"print","value":"0022-3492"},{"type":"electronic","value":"1943-3670"}],"subject":[],"published":{"date-parts":[[2003,4]]}}}