{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T10:07:31Z","timestamp":1763201251976,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2003,9,1]],"date-time":"2003-09-01T00:00:00Z","timestamp":1062374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The study of occlusal therapy in humans with periodontitis is problematic due to potential irreversible bone loss in control subjects. The hypothesis of this pilot investigation was that increased interocclusal contact initiated by shortterm occlusal splint disuse would increase tooth mobility and the bone\u2010resorptive cytokine interleukin (IL)\u20101\u03b2 in gingival crevicular fluid (GCF), comparable to IL\u20101\u2013positive genotype and increased periodontitis severity.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Nineteen non\u2010smoking chronic periodontitis patients using nocturnal occlusal splints and undergoing periodontal maintenance in a private practice were evaluated at five time points: 24 hours after continuous splint use; 1, 2, and 3 days after no occlusal splint use; and 14 days after resumption of customary nighttime splint use. Subjects were evaluated to confirm that the plaque index and gingival index were \u22641.0, and to categorize past periodontitis (moderate or severe) and IL\u20101 genotype (1A +4845 plus IL\u20101B +3954). Test sites on two anterior teeth vulnerable to occlusal trauma were sampled for mobility, GCF IL\u20101\u03b2, and IL\u20101 receptor antagonist (ra).<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Tooth mobility remained low during the 3\u2010day period when patients were not wearing their occlusal appliance. GCF IL\u2010 1\u03b2 decreased after not wearing the appliances (<jats:italic>P<\/jats:italic> = 0.016), especially at 48 hours. At this time, genotype\u2010positive subjects had higher levels of GCF IL\u20101\u03b2\/IL\u20101ra than genotype\u2010negative subjects (<jats:italic>P<\/jats:italic> = 0.045), and patients who had experienced severe periodontitis had higher IL\u20101\u03b2 levels than moderate periodontitis subjects (<jats:italic>P<\/jats:italic> = 0.004).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> These findings suggest that short\u2010term discontinuation of occlusal splint therapy in non\u2010smoking periodontitis patients undergoing periodontal maintenance does not result in potential signs of early occlusal trauma (increasing mobility or GCF IL\u20101\u03b2). Longer\u2010term studies may be needed to determine appropriate therapy applications for periodontitis\u2010susceptible patients with definable occlusal discrepancies and\/or parafunction. <jats:italic>J Periodontol 2003;74:1302\u20101307<\/jats:italic>.<\/jats:p>","DOI":"10.1902\/jop.2003.74.9.1302","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T07:51:44Z","timestamp":1107330704000},"page":"1302-1307","source":"Crossref","is-referenced-by-count":14,"title":["Impact of Increased Occlusal Contact, Interleukin\u20101 Genotype, and Periodontitis Severity on Gingival Crevicular Fluid IL\u20101\u03b2 Levels"],"prefix":"10.1002","volume":"74","author":[{"given":"Michael J.","family":"McDevitt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl M.","family":"Russell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marian J.","family":"Schmid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A.","family":"Reinhardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,9]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2003.74.9.1302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:15:10Z","timestamp":1760876110000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2003.74.9.1302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,9]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2003,9]]}},"alternative-id":["10.1902\/jop.2003.74.9.1302"],"URL":"https:\/\/doi.org\/10.1902\/jop.2003.74.9.1302","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"type":"print","value":"0022-3492"},{"type":"electronic","value":"1943-3670"}],"subject":[],"published":{"date-parts":[[2003,9]]}}}