{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T06:32:06Z","timestamp":1768631526981,"version":"3.49.0"},"reference-count":0,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2003,9,1]],"date-time":"2003-09-01T00:00:00Z","timestamp":1062374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Microbial associations in aggressive periodontitis versus different ethnic origins are substantially unknown. We undertook this study to determine the prevalence of seven putative periodontopathogens in Korean patients and to evaluate microbial differences in localized and generalized aggressive periodontitis patients.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Thirty\u2010nine aggressive periodontitis patients between 20 and 35 years old (24 males and 15 females; mean age 29.6 years) were selected according to clinical criteria. The patients were subclassified into 17 localized and 22 generalized aggressive periodontitis patients. In each of the 39 individuals, subgingival plaque samples were collected from four diseased teeth (\u22656 mm probing depth, 156 sites) and one healthy site (\u22643 mm probing depth, 39 sites). Polymerase chain reaction (PCR) of the 16S ribosomal RNA gene fragments (about 530 bp) of plaque bacteria and their subsequent detection by dot\u2010blot hybridization using specific oligonucleotide probes were performed to determine the presence of seven periodontopathogens.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The prevalences were 75% for <jats:italic>Actinobacillus actinomycetemcomitans<\/jats:italic>, 94.2% for Tannerella forsythensis (formerly Bacteroides forsythus), 99.4% for <jats:italic>Fusobacterium sp<\/jats:italic>., 85.9% for <jats:italic>Micromonas micros<\/jats:italic> (formerly <jats:italic>Peptostreptococcus micros<\/jats:italic>), 96.8% for <jats:italic>Porphyromonas gingivalis<\/jats:italic>, 78.8% for <jats:italic>Prevotella intermedia<\/jats:italic>, and 96.8% for <jats:italic>Treponema sp<\/jats:italic>. The prevalences of these bacteria were significantly higher in diseased sites than in healthy sites. Logistic regression analysis showed that <jats:italic>P. intermedia<\/jats:italic> was more significantly associated with generalized aggressive periodontitis than the localized form, with an odds ratio of 3.28 (95% con\u2010 fidence interval 1.26\u20108.56, <jats:italic>P<\/jats:italic> = 0.015).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Our results demonstrate that the seven periodontal pathogens analyzed are strongly associated with Korean aggressive periodontitis. In particular, <jats:italic>P. intermedia<\/jats:italic> are more significantly associated with generalized aggressive periodontitis, a more severe and progressive form, than with localized aggressive periodontitis. <jats:italic>J Periodontol 2003;74:1329\u20101335<\/jats:italic>.<\/jats:p>","DOI":"10.1902\/jop.2003.74.9.1329","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T07:51:44Z","timestamp":1107330704000},"page":"1329-1335","source":"Crossref","is-referenced-by-count":40,"title":["Distribution of Periodontal Pathogens in Korean Aggressive Periodontitis"],"prefix":"10.1002","volume":"74","author":[{"given":"Jung\u2010Wook","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bong\u2010Kyu","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun\u2010Jung","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong\u2010Ho","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoo\u2010Sung","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung\u2010Kiu","family":"Chai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong\u2010Kwan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,9]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2003.74.9.1329","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:15:12Z","timestamp":1760876112000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2003.74.9.1329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,9]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2003,9]]}},"alternative-id":["10.1902\/jop.2003.74.9.1329"],"URL":"https:\/\/doi.org\/10.1902\/jop.2003.74.9.1329","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,9]]}}}