{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T23:04:24Z","timestamp":1778972664803,"version":"3.51.4"},"reference-count":0,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold><jats:italic>Porphyromonas gingivalis<\/jats:italic> (<jats:italic>P. gingivalis<\/jats:italic>) is a major pathogen related to periodontitis. There are few reports on the prevalence and effect of <jats:italic>P. gingivalis<\/jats:italic> in children. The purpose of the present study was to describe in children the level of DNA\u2010<jats:italic>P. gingivalis<\/jats:italic> in subgingival plaque and the IgG serum reactivity to <jats:italic>P. gingivalis<\/jats:italic> (IgG\u2010Pg), and examine their relationship to demographic, systemic, and oral variables.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Thirty\u2010four children, aged 1.83 to 13.42 years, were included in the study; 16 with no systemic disease and 18 with systemic conditions. The demographic data for caries incidence, plaque and gingival indices, probing depth, and alveolar bone height were recorded. The IgG\u2010Pg and DNA\u2010Pg levels were determined by enzyme\u2010linked immunosorbent assay and DNA\u2010DNA hybridization, respectively. The relationships between the IgG\u2010Pg and DNA\u2010Pg values to the demographics, oral parameters, and systemic conditions were examined.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> IgG\u2010Pg was evident in 53% of the children and DNAPg in 47%. IgG\u2010Pg values significantly correlated positively with age, plaque index, and bone height. DNA\u2010Pg values had statistically significant positive correlations with age. IgG\u2010Pg and DNAPg values correlated with probing depth among children with systemic diseases. Neither the IgG\u2010Pg nor the DNA\u2010Pg values had a significant correlation to systemic conditions. Multiple regression analyses indicated that only age remained significantly related to IgG\u2010Pg and DNA\u2010Pg values.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold><jats:italic>P. gingivalis<\/jats:italic> can be found in significant levels in the plaque of young children and elicits an immune reaction that increases with age and may be related to incipient signs of periodontal disease. Plaque DNA\u2010Pg and serum IgG\u2010Pg levels correlate significantly. <jats:italic>J Periodontol 2004;75:1371\u20101376<\/jats:italic>.<\/jats:p>","DOI":"10.1902\/jop.2004.75.10.1371","type":"journal-article","created":{"date-parts":[[2005,2,17]],"date-time":"2005-02-17T11:00:38Z","timestamp":1108638038000},"page":"1371-1376","source":"Crossref","is-referenced-by-count":12,"title":["The Relationship Between <i>Porphyromonas gingivalis<\/i> Infection and Local and Systemic Factors in Children"],"prefix":"10.1002","volume":"75","author":[{"given":"Enrique","family":"Bimstein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shabetai","family":"Sapir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yael","family":"Houri\u2010Haddad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serge","family":"Dibart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas E.","family":"Van Dyke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lior","family":"Shapira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2004.75.10.1371","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:20:23Z","timestamp":1760872823000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2004.75.10.1371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2004,10]]}},"alternative-id":["10.1902\/jop.2004.75.10.1371"],"URL":"https:\/\/doi.org\/10.1902\/jop.2004.75.10.1371","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,10]]}}}