{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:35:33Z","timestamp":1760920533352,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Genetic polymorphisms for interleukin (IL)\u20101\u03b1 and \u20101\u03b2 have been proposed as potential genetic markers for periodontal diseases. Since the prevalence of these polymorphisms could be race\u2010related, and no data exist about the frequency of these polymorphisms in the Chilean population, the aim of the current study was to investigate the association of the interleukin\u20101 gene polymorphisms with aggressive periodontitis (AgP).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Thirty\u2010six patients with AgP, 75 healthy controls, and 75 subjects of unknown periodontal status (reference population) were genotyped for the IL\u20101A \u2013889 and IL\u20101B +3954 loci, by polymerase chain reaction (PCR) amplification followed by restriction enzyme digestion and gel electrophoresis. Data were analyzed using the chi\u2010square test, calculating odds ratios (OR) and confidence intervals (CI).<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The prevalence of the positive composite IL\u20101 genotype was higher in patients (25%) than in healthy controls (12%), but the difference was not significant (<jats:italic>P<\/jats:italic> = 0.14). The IL\u20101B +3954 homozygous for allele 1 frequency was higher in controls than in patients suggesting a protective factor for AgP. The heterozygous for allele 2 of the IL\u20101B showed a significant association with AgP (OR = 2.86, 95% CI 1.06 to 7.71, <jats:italic>P<\/jats:italic> = 0.030). No association was observed in localized AgP and generalized AgP between the extent of disease and the presence of the composite positive genotype. Because the number of smokers was too small in patients and in controls, no other analyses were performed.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The results of the present study support a positive association between AgP and the presence of the IL\u20101B +3954 allele 2 polymorphism. <jats:italic>J Periodontol 2004;75:1509\u20101515<\/jats:italic>.<\/jats:p>","DOI":"10.1902\/jop.2004.75.11.1509","type":"journal-article","created":{"date-parts":[[2005,2,17]],"date-time":"2005-02-17T11:00:08Z","timestamp":1108638008000},"page":"1509-1515","source":"Crossref","is-referenced-by-count":37,"title":["Association of Interleukin\u20101 Polymorphisms With Aggressive Periodontitis"],"prefix":"10.1002","volume":"75","author":[{"given":"Leticia","family":"Quappe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilian","family":"Jara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00e9stor J.","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,11]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2004.75.11.1509","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:17:16Z","timestamp":1760876236000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2004.75.11.1509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["10.1902\/jop.2004.75.11.1509"],"URL":"https:\/\/doi.org\/10.1902\/jop.2004.75.11.1509","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"type":"print","value":"0022-3492"},{"type":"electronic","value":"1943-3670"}],"subject":[],"published":{"date-parts":[[2004,11]]}}}