{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:14:20Z","timestamp":1767651260697,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:p><jats:italic><jats:bold>Background:<\/jats:bold> Ehlers\u2010Danlos syndrome (EDS) is a group of collagen disorders primarily affecting the skin and joints. This case report describes the periodontal management of a case of hypermobile EDS (type III) associated with atypical gingivitis<\/jats:italic>.<\/jats:p><jats:p><jats:italic><jats:bold>Methods:<\/jats:bold> A 17\u2010year\u2010old Caucasian female with a history of EDS type III presented with erythematous mucogingival lesions. An incisional biopsy was taken. The treatment objective was to control the mucogingival inflammatory lesions. Plaque control measures were followed with anti\u2010inflammatory medications. Prednisone was administered systemically for 3 weeks (first week: 30 mg\/day, second week: 15 mg\/day, and third week: 5 mg\/day), and was followed with topical applications of clobetasol (0.05%) twice daily for 2 weeks. Persistent marginal gingival inflammation was managed with a 3\u2010month course of doxycycline (20 mg) twice\/day. The patient was placed on a 3\u2010month maintenance program and monitored for over a year<\/jats:italic>.<\/jats:p><jats:p><jats:italic><jats:bold>Results:<\/jats:bold> Histopathology showed multiple granulomas enclosing fragments of crystalline foreign material. Steriodal anti\u2010inflammatory medications partially reduced the size and intensity of the mucogingival lesions. Doxycycline controlled the residual marginal inflammation. A 3\u2010month maintenance interval helped in maintaining the results obtained<\/jats:italic>.<\/jats:p><jats:p><jats:italic><jats:bold>Conclusions:<\/jats:bold> The collagen disorder may have facilitated the introduction and lodging of foreign material within the gingival tissues, initiating a foreign body reaction. Poor healing associated with EDS excluded surgical excision and necessitated the use of anti\u2010inflammatory medications. A combined approach of plaque control measures along with anti\u2010inflammatory medications was helpful in controlling the mucogingival inflammatory lesions associated with this condition<\/jats:italic>. J Periodontol 2004;75:1547\u20101552.<\/jats:p>","DOI":"10.1902\/jop.2004.75.11.1547","type":"journal-article","created":{"date-parts":[[2005,2,17]],"date-time":"2005-02-17T11:00:08Z","timestamp":1108638008000},"page":"1547-1552","source":"Crossref","is-referenced-by-count":3,"title":["Use of Anti\u2010Inflammatory Medications in Managing Atypical Gingivitis Associated With Hypermobile Ehlers\u2010Danlos Syndrome: A Case Report"],"prefix":"10.1002","volume":"75","author":[{"given":"Ahmed","family":"Khocht","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Calem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Deasy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,11]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2004.75.11.1547","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:17:17Z","timestamp":1760876237000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2004.75.11.1547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["10.1902\/jop.2004.75.11.1547"],"URL":"https:\/\/doi.org\/10.1902\/jop.2004.75.11.1547","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"type":"print","value":"0022-3492"},{"type":"electronic","value":"1943-3670"}],"subject":[],"published":{"date-parts":[[2004,11]]}}}