{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T12:58:26Z","timestamp":1780318706027,"version":"3.54.1"},"reference-count":0,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> We investigated the effect of oral alendronate (ALN) treatment on radiological and clinical measurements of periodontal disease in postmenopausal women without hormone replacement therapy.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> We evaluated the effect of 6 months of ALN treatment in 40 postmenopausal women, 55 to 65 years old with established periodontal disease, in a controlled, double\u2010masked, prospective study. Volunteers were paired by age and randomized to receive ALN (10 mg\/day) or placebo for the study period. Periodontal mechanical treatment was carried out in both groups. At baseline and after treatment, clinical evaluation, hormone blood levels, distance from the crestal alveolar bone (CAB) to the cemento\u2010enamel junction (CEJ), calcaneus bone mineral density (BMD), hormone levels, serum N\u2010telopeptide (NTx), and bone\u2010specific alkaline phosphatase (BSAP) were assessed.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Periodontal disease conditions improved in both groups, but greater improvement in probing depth (\u20130.8 \u00b1 0.3 mm versus \u20130.4 \u00b1 0.4 mm, P = 0.02) and gingival bleeding (\u20130.3% \u00b1 0.13% versus \u20130.2% \u00b1 0.06%, P = 0.006) was found in the ALN treated group. Calcaneus BMD increased in the ALN treated group (68 \u00b1 47 mm<jats:sup>3<\/jats:sup> versus \u201326 \u00b1 81 mm<jats:sup>3<\/jats:sup>, P = 0.0006). CAB\u2010CEJ distance diminished in the ALN group (\u20130.4 \u00b1 0.40 mm versus 0.60 \u00b1 0.53 mm, P = 0.00008). Marginal reduction in both NTx and BSAP levels was found in the ALN group (\u20139.4 \u00b1 6.6 nmol versus \u20134.3 \u00b1 4.7 nmol bone collagen equivalents, P = 0.08, and \u20137.7 \u00b1 8.4 versus \u20131.5 \u00b1 5.0 U\/l, P = 0.1, respectively). Hormone levels were unchanged after treatment. Similar improvement of calcaneus BMD and CAB\u2010CEJ distance with ALN treatment was found in obese and non\u2010obese women.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> ALN treatment improved periodontal disease and bone turnover in postmenopausal women. <jats:italic>J Periodontol 2004; 75:1579\u20101585<\/jats:italic>.<\/jats:p>","DOI":"10.1902\/jop.2004.75.12.1579","type":"journal-article","created":{"date-parts":[[2005,2,23]],"date-time":"2005-02-23T16:06:20Z","timestamp":1109174780000},"page":"1579-1585","source":"Crossref","is-referenced-by-count":90,"title":["Effect of Alendronate on Periodontal Disease in Postmenopausal Women: A Randomized Placebo\u2010Controlled Trial"],"prefix":"10.1002","volume":"75","author":[{"given":"Miriam L.","family":"Rocha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan M.","family":"Malacara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"S\u00e1nchez\u2010Marin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos J. Vazquez","family":"de la Torre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha E.","family":"Fajardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,12]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2004.75.12.1579","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:04:08Z","timestamp":1760868248000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2004.75.12.1579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["10.1902\/jop.2004.75.12.1579"],"URL":"https:\/\/doi.org\/10.1902\/jop.2004.75.12.1579","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12]]}}}