{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:25:52Z","timestamp":1760919952947,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Cyclosporin A (CsA) is an immunosuppressant widely used to treat transplant patients and various systemic diseases with immunological components. Gingival overgrowth (GO) is a common side effect of CsA administration; however, the pathogenesis of drug\u2010induced GO is poorly understood. The aim of this study was to evaluate the expression of Ki\u201067, activation molecules (CD71, CD98), leukocytes activation antigens (CD45, CD45RA, CD50, CD11a, CD162, CD227, CD231), neurothelin (CD147), and novel endothelial cell antigens (B\u2010F45, SCF87, BD46, B\u2010C44, VJ1\/6) in gingival tissue in renal transplant recipients treated with CsA.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Tissues from 15 renal transplant patients with significant GO and 10 systemically healthy control subjects with gingivitis were studied. Frozen\u2010section biopsies were stained with monoclonal antibodies specific for the above\u2010mentioned antigens using an indirect immunoperoxidase technique.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Comparison of the CsA\u2010treated and control groups revealed no significant differences with respect to expression of Ki\u201067; CD50; activation molecules; neurothelin; or novel endothelial cell antigens B\u2010D46, B\u2010C44, and VJ1\/6. However, expression patterns of CD45, CD45RA, CD11a, CD162, CD227, CD231, B\u2010F45, and SCF87 were significantly different in CsA and control groups.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Leukocyte activation antigens play an important role in CsA\u2010induced gingival overgrowth. <jats:italic>J Periodontol 2004;75:1655\u20101662<\/jats:italic>.<\/jats:p>","DOI":"10.1902\/jop.2004.75.12.1655","type":"journal-article","created":{"date-parts":[[2005,2,23]],"date-time":"2005-02-23T16:06:20Z","timestamp":1109174780000},"page":"1655-1662","source":"Crossref","is-referenced-by-count":7,"title":["Immunohistochemical Study of Cyclosporin\u2010Induced Gingival Overgrowth in Renal Transplant Recipients"],"prefix":"10.1002","volume":"75","author":[{"given":"\u00d6mer Engin","family":"Bulut","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lale Karako\u00e7","family":"S\u00f6kmens\u00fcer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015eule","family":"Bulut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00fcgen","family":"Tasman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sevda","family":"M\u00fcft\u00fcog\u0360lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,12]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2004.75.12.1655","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:04:12Z","timestamp":1760868252000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2004.75.12.1655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["10.1902\/jop.2004.75.12.1655"],"URL":"https:\/\/doi.org\/10.1902\/jop.2004.75.12.1655","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"type":"print","value":"0022-3492"},{"type":"electronic","value":"1943-3670"}],"subject":[],"published":{"date-parts":[[2004,12]]}}}