{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T11:41:01Z","timestamp":1776858061962,"version":"3.51.2"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,2,1]],"date-time":"2004-02-01T00:00:00Z","timestamp":1075593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2004,2]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Studies utilizing collagen membranes for guided tissue regeneration (GTR)\u2010based root coverage procedures have reported promising results. However, creating and maintaining space underneath the membrane remains a challenge. Therefore, the purpose of this clinical trial was to determine whether the addition of bone graft (i.e., demineralized freeze\u2010dried bone allograft [DFDBA]) significantly affects the outcome of collagen membrane GTR\u2010based root coverage procedures.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Twenty patients participated. One Miller's Class I or II recession defect per patient was treated with a collagen membrane covered by a coronally positioned flap. Half of the patients also had DFDBA placed under the membrane. Clinical parameters recorded included: recession depth, recession width, width of keratinized tissue, clinical attachment level, and probing depth, measured to the nearest 0.5 mm. Presurgery and postsurgery (6\u2010month) data were compared using Student's paired <jats:italic>t<\/jats:italic> test for parametric data and the Wilcoxon matched pairs test for non\u2010parametric data.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Guided tissue regeneration with collagen (COLL) and collagen + DFDBA (COBA) both resulted in statistically signifi\u2010 cant (<jats:italic>P<\/jats:italic> &lt;0.05) reductions in recession depth (2.1 \u00b1 0.9 mm and 2.5 \u00b1 0.5 mm), recession width (1.5 \u00b1 1.7 mm and 2.2 \u00b1 1.6 mm), increase in keratinized tissue (0.7 \u00b1 0.8 mm and 1.2 \u00b1 1.0 mm), and gain of clinical attachment level (2.1 \u00b1 1.0 mm and 3.0 \u00b1 1.0 mm), when comparing 6\u2010month data to baseline. Mean root coverage was 68.4 \u00b1 15.2% with COLL and 74.3 \u00b1 11.7% with COBA. However, there were no statistically significant differences between groups for recession depth, recession width, width of keratinized tissue, clinical attachment level, and probing depth.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Both techniques are effective in attaining root coverage. Although root coverage tended to be better with the addition of DFDBA, the difference was not statistically significant. Further studies with a larger sample size are needed to determine whether adding DFDBA to GTR\u2010based procedures using collagen membranes is of any benefit. <jats:italic>J Periodontol 2004;75:210\u2010220<\/jats:italic>.<\/jats:p>","DOI":"10.1902\/jop.2004.75.2.210","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T07:48:34Z","timestamp":1107330514000},"page":"210-220","source":"Crossref","is-referenced-by-count":42,"title":["Treatment of Gingival Recession Using a Collagen Membrane with or without the Use of Demineralized Freeze\u2010Dried Bone Allograft for Space Maintenance"],"prefix":"10.1002","volume":"75","author":[{"given":"Kenneth M.","family":"Kimble","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M.","family":"Eber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Soehren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Shyr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hom\u2010Lay","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,2]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2004.75.2.210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:32:42Z","timestamp":1760869962000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2004.75.2.210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,2]]}},"alternative-id":["10.1902\/jop.2004.75.2.210"],"URL":"https:\/\/doi.org\/10.1902\/jop.2004.75.2.210","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,2]]}}}