{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:04:27Z","timestamp":1790474667817,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,2,1]],"date-time":"2004-02-01T00:00:00Z","timestamp":1075593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2004,2]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The objective of this study was to histologically evaluate periodontal healing following flap surgery in intrabony periodontal defects to determine the influence of the number of bone walls on periodontal regeneration.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> One\u2010, 2\u2010, and 3\u2010wall intrabony periodontal defects were surgically produced at the proximal aspect of mandibular premolars in either right or left jaw quadrants in six beagle dogs. Mucoperiosteal flaps were positioned and sutured to their presurgery position following defect preparation. The animals were euthanized at 8 weeks post\u2010surgery, and block sections of the defect sites were collected for histologic and histometric analysis.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Bone and cementum regeneration was positively correlated to the number of bone walls limiting the intrabony periodontal defects. The junctional epithelium averaged (\u00b1 SD) 1.5 \u00b1 0.2, 1.2 \u00b1 0.3, and 0.9 \u00b1 0.2 mm for the 1\u2010, 2\u2010, and 3\u2010wall defects, respectively, with the 3\u2010wall defects being significantly different from the 1\u2010wall defects (<jats:italic>P<\/jats:italic> &lt;0.05). Cementum regeneration averaged 1.2 \u00b1 0.6, 2.0 \u00b1 0.6, and 2.8 \u00b1 0.5 mm for the 1\u2010, 2\u2010, and 3\u2010wall defects, respectively; all groups were significantly different from each other (<jats:italic>P<\/jats:italic> &lt;0.05). Bone regeneration averaged 1.5 \u00b1 0.5, 1.7 \u00b1 0.6, and 2.3 \u00b1 0.5 mm for the 1\u2010, 2\u2010, and 3\u2010wall defects, respectively, with the 3\u2010wall defects being significantly different from the 1\u2010wall defects (<jats:italic>P<\/jats:italic> &lt;0.05).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> The results suggest that the number of bone walls is a critical factor determining treatment outcomes in intrabony periodontal defects. One\u2010 and 3\u2010wall intrabony defects appear to be reproducible models to evaluate candidate technologies for periodontal regeneration. <jats:italic>J Periodontol 2004:75:229\u2010235<\/jats:italic>.<\/jats:p>","DOI":"10.1902\/jop.2004.75.2.229","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T07:48:34Z","timestamp":1107330514000},"page":"229-235","source":"Crossref","is-referenced-by-count":106,"title":["Periodontal Repair in Surgically Created Intrabony Defects in Dogs: Influence of the Number of Bone Walls on Healing Response"],"prefix":"10.1002","volume":"75","author":[{"given":"Chang\u2010Sung","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong\u2010Ho","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung\u2010Kiu","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoo\u2010Sung","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ik\u2010Sang","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf M.E.","family":"Wikesj\u00f6","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong\u2010Kwan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,2]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2004.75.2.229","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:32:43Z","timestamp":1760869963000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2004.75.2.229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,2]]}},"alternative-id":["10.1902\/jop.2004.75.2.229"],"URL":"https:\/\/doi.org\/10.1902\/jop.2004.75.2.229","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,2]]}}}