{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:26:48Z","timestamp":1783524408966,"version":"3.55.0"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2004,3]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The acute\u2010phase response involves molecules including tumor necrosis factor\u2010alpha (TNF\u2010\u03b1), interleukin\u20106 (IL\u20106), and C\u2010reactive protein (CRP). This study aimed to determine whether subgingival scaling resulted in rapid changes in plasma concentrations of these molecules.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Twenty\u2010three non\u2010smoking adults with chronic periodontitis received subgingival scaling for 60 minutes. Venous blood samples were taken at 0, 15, 30, 60, and 120 minutes. TNF\u2010 \u03b1 and IL\u20106 were assayed from all samples and CRP from the baseline and final samples. Lipopolysaccharide (LPS) was assayed at 0, 15, and 30 minutes using limulus lysate assay (LAL) and EndoCAb Ig assays.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> LPS assays were suggestive of a transient low\u2010grade bacteremia, but changes in LPS approaching significance (<jats:italic>P<\/jats:italic> = 0.061) were seen with LAL only. There was a significant increase in circulating TNF\u2010\u03b1 (<jats:italic>P<\/jats:italic> = 0.0387) and IL\u20106 (<jats:italic>P<\/jats:italic> &lt;0.0001), and the degree of change in TNF\u2010\u03b1 was correlated with the severity of periodontal breakdown (<jats:italic>P<\/jats:italic> = 0.001). There was also a significant correlation between levels of IL\u20106 and TNF\u2010\u03b1 (<jats:italic>P<\/jats:italic> &lt;0.001).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Chronic periodontitis patients undergoing an episode of subgingival scaling show a significant elevation in circulating TNF\u2010\u03b1 and IL\u20106. This may account for anecdotal reports of pyrexia following treatment and may be significant in terms of the relationship between periodontal disease, bacteremia, and cardiovascular disease. <jats:italic>J Periodontol 2004;75:420\u2010428<\/jats:italic>.<\/jats:p>","DOI":"10.1902\/jop.2004.75.3.420","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T07:52:16Z","timestamp":1107330736000},"page":"420-428","source":"Crossref","is-referenced-by-count":96,"title":["The Short\u2010Term Effects of Treatment of Chronic Periodontitis on Circulating Levels of Endotoxin, C\u2010Reactive Protein, Tumor Necrosis Factor\u2010\u03b1, and Interleukin\u20106"],"prefix":"10.1002","volume":"75","author":[{"given":"Mark","family":"Ide","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daljit","family":"Jagdev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Y.","family":"Coward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Crook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Robin","family":"Barclay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron F.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,3]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2004.75.3.420","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:35:22Z","timestamp":1760873722000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2004.75.3.420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,3]]}},"alternative-id":["10.1902\/jop.2004.75.3.420"],"URL":"https:\/\/doi.org\/10.1902\/jop.2004.75.3.420","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,3]]}}}