{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T10:07:25Z","timestamp":1763201245507,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2004,3]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The aim of this clinical study was to evaluate the association of locally delivered doxycycline (10%) with scaling and root planing in the periodontal treatment of smokers.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Forty\u2010three patients with chronic periodontitis and a minimum of four pockets (\u22655 mm) on anterior teeth that bled on probing were selected. Patients were randomly assigned to scaling and root planing (SRP) or scaling and root planing followed by local application of doxycycline (SRP\u2010D). Plaque, bleeding on probing, gingival recession, relative attachment level RAL), and probing depth (PD) were recorded at baseline, 45 days, and 3 and 6 months. Differences between baseline and each period were considered for analysis.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> At 6 months, no difference was found between groups regarding plaque, bleeding reduction, gingival recession or PD (<jats:italic>P<\/jats:italic> &gt;0.05). However, RAL gain was greater for SRP\u2010D (1.63 \u00b1 0.93 mm) than for SRP (1.04 \u00b1 0.71 mm) (<jats:italic>P<\/jats:italic> = 0.025). In addition, deep pockets (\u22657 mm) showed a significant reduction (3.78 \u00b1 1.41 versus 2.60 \u00b1 1.28 mm, <jats:italic>P<\/jats:italic> = 0.039) and RAL gain (2.54 \u00b1 1.27 mm versus 1.29 \u00b1 0.95 mm, <jats:italic>P<\/jats:italic> = 0.01) when doxycycline was applied. The proportion of sites showing RAL gain of 1 to 2 mm was 36.8% versus 21.7% for SRP\u2010D and SRP, respectively (<jats:italic>P<\/jats:italic> = 0.01).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The use of locally delivered doxycycline may constitute an important adjunct for the treatment of severe periodontal disease in smokers. <jats:italic>J Periodontol 2004;75:464\u2010469<\/jats:italic>.<\/jats:p>","DOI":"10.1902\/jop.2004.75.3.464","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T07:52:16Z","timestamp":1107330736000},"page":"464-469","source":"Crossref","is-referenced-by-count":24,"title":["Locally Delivered Doxycycline as an Adjunctive Therapy to Scaling and Root Planing in the Treatment of Smokers: A Clinical Study"],"prefix":"10.1002","volume":"75","author":[{"given":"Luciana","family":"Machion","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise Carleto","family":"Andia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno Braga","family":"Benatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo Diniz","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Get\u00falio R.","family":"Nogueira\u2010Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcio Zafallon","family":"Casati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Francisco H.","family":"Nociti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enilson Antonio","family":"Sallum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,3]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2004.75.3.464","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:35:23Z","timestamp":1760873723000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2004.75.3.464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,3]]}},"alternative-id":["10.1902\/jop.2004.75.3.464"],"URL":"https:\/\/doi.org\/10.1902\/jop.2004.75.3.464","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"type":"print","value":"0022-3492"},{"type":"electronic","value":"1943-3670"}],"subject":[],"published":{"date-parts":[[2004,3]]}}}