{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T23:49:36Z","timestamp":1768002576006,"version":"3.49.0"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> This randomized, double\u2010masked, placebocontrolled clinical trial evaluated the effect of enamel matrix derivative (EMD) on clinical and radiographic parameters of periodontal intrabony defects.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A split\u2010mouth design was used in 16 chronic periodontitis patients who had similar defects (\u22656 mm of probing depth). Both groups underwent scaling and root planing and were acid\u2010etched with EDTA. The test sites received the EMD solution and the controls a placebo. Clinical examinations of all 16 patients and radiographs of 14 patients were available at baseline and 6 and 12 months after surgery. Clinical outcomes included probing depth (PD) and clinical attachment level (CAL); radiographic analysis was performed using computerized linear measurements. Intergroup comparisons were performed by paired samples t test, and over time comparisons were made by general linear model (\u03b1 = 0.05).<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> A statistically significant improvement over time for PD and CAL and a decrease of the vertical component of the defect was detected in both groups. Comparisons between groups revealed at baseline a mean \u00b1 SD value of CAL of 12.93 \u00b1 2.00 and 13.47 \u00b1 2.93 for test and control groups, respectively. These values decreased to 10.92 \u00b1 1.92 and 11.31 \u00b1 1.86 after 12 months for test and control. No statistically significant differences could be observed between groups. PD displayed similar results from 7.57 \u00b1 1.02 and 7.38 \u00b1 1.16 for test and control groups at baseline to 3.40 \u00b1 1.82 and 2.99 \u00b1 1.07 after 12 months. If the data are divided into smokers and non\u2010smokers, no differences are observed.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Use of EMD did not result in more improvement in clinical and radiographic parameters compared to the placebo. <jats:italic>J Periodontol 2005;76:129\u2010133<\/jats:italic>.<\/jats:p>","DOI":"10.1902\/jop.2005.76.1.129","type":"journal-article","created":{"date-parts":[[2005,3,7]],"date-time":"2005-03-07T08:41:10Z","timestamp":1110184870000},"page":"129-133","source":"Crossref","is-referenced-by-count":43,"title":["Clinical and Radiographic Effects of Enamel Matrix Derivative in the Treatment of Intrabony Periodontal Defects: A 12\u2010Month Longitudinal Placebo\u2010Controlled Clinical Trial in Adult Periodontitis Patients"],"prefix":"10.1002","volume":"76","author":[{"given":"Cassiano K.","family":"R\u00f6sing","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne M.","family":"Aass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonios","family":"Mavropoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Gjermo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,1]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2005.76.1.129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:52:35Z","timestamp":1760878355000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2005.76.1.129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["10.1902\/jop.2005.76.1.129"],"URL":"https:\/\/doi.org\/10.1902\/jop.2005.76.1.129","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,1]]}}}