{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:00:57Z","timestamp":1791194457660,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,10,1]],"date-time":"2005-10-01T00:00:00Z","timestamp":1128124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> <jats:italic>Porphyromonas gingivalis<\/jats:italic> is considered a critical pathogen in periodontal diseases. It is classified into six genotypes based on diversity of the <jats:italic>fimA<\/jats:italic> gene encoding fimbrillin. The present study evaluated the involvement of the <jats:italic>fimA<\/jats:italic> genotype in treatment outcome following non\u2010surgical periodontal therapy.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Chronic periodontitis patients were enrolled in this study; all received clinical and microbiological examinations at baseline. The detection of subgingival species and identification of <jats:italic>P. gingivalis fimA<\/jats:italic> genotypes were performed using polymerase chain reaction based methods. In total, 160 <jats:italic>P. gingivalis<\/jats:italic> positive sites with bleeding on probing (BOP) and a probing depth of \u22654 mm were accepted. They were followed up after scaling and root planing.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Longitudinal investigation indicated that <jats:italic>fimA<\/jats:italic> type I positive sites at baseline were followed by a significantly higher frequency of persistent BOP after treatment than type I negative sites (51.6% versus 27.9%), while types Ib and II were not. Type I positive sites also showed more persistence of <jats:italic>Tannerella forsythensis<\/jats:italic> and <jats:italic>P. gingivalis<\/jats:italic> after treatment than type I negative sites. In post\u2010treatment investigation, type I positive sites showed higher frequencies of BOP and <jats:italic>T. forsythensis<\/jats:italic> detection than type I negative sites (77.8% versus 43.5% and 100% versus 76.1%, respectively).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> BOP in initially type I positive sites showed little improvement with treatment, and the combined persistence of <jats:italic>fimA<\/jats:italic> type I and <jats:italic>T. forsythensis<\/jats:italic> seemed to be involved in this poor treatment outcome. The present study demonstrated the potential of <jats:italic>P. gingivalis fimA<\/jats:italic> type I as a predictor of persistent BOP after treatment.<\/jats:p>","DOI":"10.1902\/jop.2005.76.10.1661","type":"journal-article","created":{"date-parts":[[2005,10,27]],"date-time":"2005-10-27T11:47:16Z","timestamp":1130413636000},"page":"1661-1666","source":"Crossref","is-referenced-by-count":10,"title":["Involvement of <i>Porphyromonas gingivalis fimA<\/i> Genotype in Treatment Outcome Following Non\u2010Surgical Periodontal Therapy"],"prefix":"10.1002","volume":"76","author":[{"given":"Osamu","family":"Fujise","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Miura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Hamachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsumasa","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,10]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2005.76.10.1661","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T08:35:19Z","timestamp":1760862919000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2005.76.10.1661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2005,10]]}},"alternative-id":["10.1902\/jop.2005.76.10.1661"],"URL":"https:\/\/doi.org\/10.1902\/jop.2005.76.10.1661","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,10]]}}}