{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T06:12:35Z","timestamp":1789711955455,"version":"4.0.1"},"reference-count":0,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Monocyte chemoattractant protein\u20101 (MCP\u20101) is a well\u2010known chemotactic cytokine that regulates mononuclear inflammatory cell recruitment. This recruitment has particular importance in the oral cavity because inflammatory cells will be challenged with periodontopathogenic bacteria during infections. Tumor necrosis factor\u2010alpha (TNF\u2010\u03b1) is a cytokine that induces bone resorption by stimulating proliferation and differentiation of osteoclasts\u2019 progenitors and also stimulates MCP\u20101 expression. The aims of this study were to investigate the presence of MCP\u20101 in gingival crevicular fluid (GCF) samples from patients with chronic periodontitis (CP) and aggressive periodontitis (AgP) and to examine the possible correlations between the GCF levels of MCP\u20101 and TNF\u2010\u03b1.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Twenty\u2010five CP, 20 AgP, and 20 healthy control (C) patients were selected for the study. Plaque index (PI), gingival index (GI), probing depth (PD), and clinical attachment level (CAL) measurements were recorded from each sampling area. Assays for GCF MCP\u20101 and TNF\u2010\u03b1 were carried out by an enzyme\u2010linked immunosorbent assay (ELISA) method.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The concentration (nanograms per microliters) and total MCP\u20101 and TNF\u2010\u03b1 (nanograms per site) were not statistically significant between CP and AgP groups, but total MCP\u20101 and TNF\u2010\u03b1 was statistically different between CP and C and between AgP and C groups (<jats:italic>P<\/jats:italic> &lt;0.001). All clinical parameters were statistically different between CP and C and between AgP and C groups (<jats:italic>P<\/jats:italic> &lt;0.001). A positive statistical correlation was detected between the levels of MCP\u20101 and TNF\u2010\u03b1, and there was also a positive correlation between all clinical parameters and total MCP\u20101 and TNF\u2010\u03b1 levels.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> These results suggest that MCP\u20101 could have an important role in the activation and recruitment of inflammatory and immune cells in periodontal diseases, and both AgP and CP patients may have the same pattern of MCP\u20101 expression. A strong positive correlation between the GCF levels of MCP\u20101 and TNF\u2010\u03b1 may account for the mechanism of amplification of inflammatory events in gingival inflammation.<\/jats:p>","DOI":"10.1902\/jop.2005.76.11.1849","type":"journal-article","created":{"date-parts":[[2005,11,7]],"date-time":"2005-11-07T13:20:15Z","timestamp":1131369615000},"page":"1849-1855","source":"Crossref","is-referenced-by-count":121,"title":["Gingival Crevicular Fluid Levels of Monocyte Chemoattractant Protein\u20101 and Tumor Necrosis Factor\u2010Alpha in Patients With Chronic and Aggressive Periodontitis"],"prefix":"10.1002","volume":"76","author":[{"given":"B\u00fclent","family":"Kurti\u015f","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fclay","family":"T\u00fcter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhittin","family":"Serdar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pelin","family":"Akdemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cem","family":"Uygur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erhan","family":"Firatli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belgin","family":"Bal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2005.76.11.1849","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:08:15Z","timestamp":1760875695000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2005.76.11.1849"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["10.1902\/jop.2005.76.11.1849"],"URL":"https:\/\/doi.org\/10.1902\/jop.2005.76.11.1849","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11]]}}}