{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T03:37:14Z","timestamp":1769398634214,"version":"3.49.0"},"reference-count":0,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Cytokines play a key role in the pathogenesis of inflammatory diseases. An obvious question is whether patients with aggressive periodontitis, juvenile idiopathic arthritis, or rheumatoid arthritis share blood cytokine profiles distinguishing them from individuals free of disease.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The study population consisted of Danish white adults, &lt;35 years of age, diagnosed with localized aggressive periodontitis (LAgP; N = 18), generalized aggressive periodontitis (GAgP; N = 27), juvenile idiopathic arthritis (JIA; N = 10), or rheumatoid arthritis (RA; N = 23) and healthy individuals with no systemic or oral diseases (control [CTRL]; N = 25). Enzyme\u2010linked immunosorbent assays were used to determine the levels of interleukin (IL)\u20101\u03b1, IL\u20101\u03b2, IL\u20101 receptor antagonist (IL\u20101Ra), IL\u20106, IL\u201010, tumor necrosis factor (TNF)\u2010\u03b1, and lymphotoxin (LT)\u2010\u03b1 in peripheral blood (plasma) and unstimulated and stimulated whole blood cell cultures from the same blood collection. Autoantibodies (aAb) to IL\u20101\u03b1 and IL\u20106 were quantitated by radioimmunoassay.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Similar patterns of slightly higher IL\u201010 levels in plasma were found for GAgP and RA patients and in unstimulated cultures for GAgP, RA, and JIA patients. Interestingly, unstimulated cultures also demonstrated similar patterns of higher TNF\u2010\u03b1 levels for these three groups of patients. Similar group patterns of periodontitis patients (LAgP and GAgP) included increased IL\u20101Ra levels in stimulated cultures, which also showed similar group patterns of arthritis patients (JIA and RA) with respect to higher IL\u20101\u03b1 and lower LT\u2010\u03b1 levels. Low titers of aAb to IL\u20101\u03b1 and IL\u20106 were found in almost all individuals.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Patients with aggressive periodontitis and types of arthritis presented with similar components of blood cytokine profiles distinguishing them from individuals free of disease.<\/jats:p>","DOI":"10.1902\/jop.2005.76.12.2276","type":"journal-article","created":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T16:44:45Z","timestamp":1133887485000},"page":"2276-2285","source":"Crossref","is-referenced-by-count":83,"title":["Cytokine Profiles in Peripheral Blood and Whole Blood Cell Cultures Associated With Aggressive Periodontitis, Juvenile Idiopathic Arthritis, and Rheumatoid Arthritis"],"prefix":"10.1002","volume":"76","author":[{"given":"Anne","family":"Havemose\u2010Poulsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars Korsb\u00e6k","family":"S\u00f8rensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaj","family":"Stoltze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Bendtzen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Palle","family":"Holmstrup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2005.76.12.2276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:02:17Z","timestamp":1760875337000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2005.76.12.2276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["10.1902\/jop.2005.76.12.2276"],"URL":"https:\/\/doi.org\/10.1902\/jop.2005.76.12.2276","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,12]]}}}