{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:15:00Z","timestamp":1763036100506,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Guillain\u2010Barr\u00e9 syndrome (GBS), an autoimmune disorder of the peripheral nervous system, is characterized by rapidly ascending neural paralysis, hyporeflexia, and areflexia. The polyneuropathy of the GBS affects one to four humans per 100,000 of the population annually throughout the world (adults and children). The pathogenesis of GBS remains unclear. However, there are increasing indications that the disease is triggered by a preceding well\u2010established febrile infection by cytomegalovirus (CMV). The present report describes active CMV within the periodontium of a 37\u2010year\u2010old patient affected by GBS.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Real\u2010time reverse transcriptase\u2010polymerase chain reaction (real\u2010time RT\u2010PCR) was performed to detect CMV, Epstein\u2010Barr virus\u20101 (EBV\u20101), herpes simplex 1 (HSV\u20101) and 2 (HSV\u20102) virus, and enteroviruses (polio\u2010, coxsackie\u2010, echo\u2010, and enteroviruses 68 and 71) from periodontal sites demonstrating advanced attachment loss. Healthy sites and sites with inflamed gingival tissue were not included in the study. Anaerobic bacterial culture determined the occurrence of potential major periodontal pathogens.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Real\u2010time RT\u2010PCR and microbiologic analysis revealed the presence of a dual infection of CMV and specific bacterial plaque. CMV, <jats:italic>Porphyromonas gingivalis<\/jats:italic>, <jats:italic>Tannerella forsythensis<\/jats:italic>, and <jats:italic>Campylobacter<\/jats:italic> species were associated with periodontitis active sites, loss of attachment, and gingival bleeding. Furthermore, periodontal sites infected by active CMV had no visible radiographic crestal lamina dura.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> The periodontium may serve as a reservoir for CMV and a source of viral replication. However, further research is needed to test whether viral replication in the periodontium precedes the GBS symptoms.<\/jats:p>","DOI":"10.1902\/jop.2005.76.12.2306","type":"journal-article","created":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T16:44:45Z","timestamp":1133887485000},"page":"2306-2311","source":"Crossref","is-referenced-by-count":11,"title":["Cytomegalovirus\u2010Associated Periodontitis and Guillain\u2010Barr\u00e9 Syndrome"],"prefix":"10.1002","volume":"76","author":[{"given":"Giorgio","family":"Tabanella","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hessam","family":"Nowzari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2005.76.12.2306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:02:19Z","timestamp":1760875339000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2005.76.12.2306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["10.1902\/jop.2005.76.12.2306"],"URL":"https:\/\/doi.org\/10.1902\/jop.2005.76.12.2306","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"type":"print","value":"0022-3492"},{"type":"electronic","value":"1943-3670"}],"subject":[],"published":{"date-parts":[[2005,12]]}}}