{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:28:43Z","timestamp":1760920123727,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Cyclosporin A (CsA) is known to induce gingival overgrowth. Apoptosis plays a critical role in the regulation of inflammation and the host immune response. The aim of this study was to investigate apoptosis in CsA\u2010induced gingival enlargement using electron microscopy examination of keratinocytes.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Gingiva specimens were collected from 12 CsA\u2010treated renal transplant patients with gingival overgrowth and eight healthy controls with gingivitis. Clinical findings (probing depth, gingival index, and plaque index) were compared in the two groups. Histological and ultrastructural features of the specimens were also compared, and extent of keratinocyte apoptosis was scored on a three\u2010tier scale: 0 = no apoptotic cells; 1 = one or two apoptotic cells; 2 = more than two cells.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> There were no significant differences between groups with respect to gingiva\u2010related clinical findings or extent of keratinocyte apoptosis.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> The results indicate that the extent of keratinocyte apoptosis in the gingiva of kidney recipients with CsA\u2010induced gingival overgrowth is similar to that observed in inflamed gingiva of healthy individuals. Further studies on apoptosis of different cell types in the presence of CsA should clarify this agent's role in the pathogenesis of drug\u2010induced gingival enlargement. <jats:italic>J Periodontol 2005;76:166\u2010170<\/jats:italic>.<\/jats:p>","DOI":"10.1902\/jop.2005.76.2.166","type":"journal-article","created":{"date-parts":[[2005,3,19]],"date-time":"2005-03-19T18:18:25Z","timestamp":1111256305000},"page":"166-170","source":"Crossref","is-referenced-by-count":7,"title":["Apoptosis in Cyclosporin A\u2010Induced Gingival Overgrowth: A Histological Study"],"prefix":"10.1002","volume":"76","author":[{"given":"Emine Elif","family":"Alaaddinog\u0360lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fclten","family":"Karabay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015eule","family":"Bulut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00fcsun Bahar","family":"Oduncuog\u0360lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Handan","family":"\u00d6zdemir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6mer Engin","family":"Bulut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Turan","family":"\u00c7olak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2005.76.2.166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:39:55Z","timestamp":1760870395000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2005.76.2.166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,2]]}},"alternative-id":["10.1902\/jop.2005.76.2.166"],"URL":"https:\/\/doi.org\/10.1902\/jop.2005.76.2.166","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"type":"print","value":"0022-3492"},{"type":"electronic","value":"1943-3670"}],"subject":[],"published":{"date-parts":[[2005,2]]}}}