{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T06:52:39Z","timestamp":1769842359494,"version":"3.49.0"},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The purpose of this study was to evaluate the efficacy, relative safety, and tolerability of 1% pimecrolimus cream in the treatment of oral erosive lichen planus (OELP).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Twenty patients with OELP were randomized into equal groups; group 1 applied 1% pimecrolimus cream twice daily to their oral lesions for 4 weeks, whereas group 2 applied a placebo cream. Photographs of the lesions were taken and analyzed for areas of ulceration, erythema, and reticulation. Discomfort scores were also assessed with a visual analogue scale (VAS). Blood samples were taken at baseline and at study completion; a complete blood count with differential and comprehensive metabolic panel was ordered. The Wilcoxon signed rank test was used.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The experimental group showed a decrease in ulceration (\u03b1 = 0.068) and erythema (\u03b1 = 0.005) at the mid\u2010point with continued reduction of erythema at the final (\u03b1 = 0.075) time measurement. The control group demonstrated an increase in reticulation at the mid\u2010point (\u03b1 = 0.017) and final (\u03b1 = 0.007) time measurement. The VAS scores for the experimental group decreased during the study (\u03b1 = 0.022). Blood levels were within the normal range.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> The OELP lesion size in the 1% pimecrolimus group decreased and the pimecrolimus cream was found to significantly reduce the patient's pain scores. Further study of 1% pimecrolimus as therapy for OELP is warranted since it was shown to be effective, relatively safe, and well tolerated by patients within the limits of this short\u2010term study. <jats:italic>J Periodontol 2005;76:627\u2010635<\/jats:italic>.<\/jats:p>","DOI":"10.1902\/jop.2005.76.4.627","type":"journal-article","created":{"date-parts":[[2005,4,27]],"date-time":"2005-04-27T05:50:25Z","timestamp":1114581025000},"page":"627-635","source":"Crossref","is-referenced-by-count":66,"title":["The Effectiveness of 1% Pimecrolimus Cream in the Treatment of Oral Erosive Lichen Planus"],"prefix":"10.1002","volume":"76","author":[{"given":"Julie C.","family":"Swift","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terry D.","family":"Rees","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline M.","family":"Plemons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William W.","family":"Hallmon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,4]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2005.76.4.627","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:32:33Z","timestamp":1760869953000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2005.76.4.627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["10.1902\/jop.2005.76.4.627"],"URL":"https:\/\/doi.org\/10.1902\/jop.2005.76.4.627","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,4]]}}}