{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T13:29:09Z","timestamp":1770038949696,"version":"3.49.0"},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Gingival overgrowth (GO) is a common side effect of cyclosporin A (CsA) therapy, but the exact mechanism for this is unknown. Apoptosis plays an important role in the maintenance of tissue homeostasis and mediators of this process may be involved in the pathogenesis of drug\u2010induced GO. This study compared p53 expression, bcl\u20102 expression, and apoptosis in gingival samples from CsA\u2010treated renal transplant recipients to findings in controls with gingivitis.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Twenty\u2010two kidney recipients with CsA\u2010induced GO and 15 systemically healthy subjects with gingivitis were included in the study. The 15 systemically and periodontally healthy volunteer control group were immunohistochemically analyzed for grades of p53 and bcl\u20102 expression, and were processed using terminal TdT\u2010mediated dUTP\u2010biotin nick\u2010end labeling (TUNEL) technique to identify and grade levels of apoptosis.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> There were no differences between the CsA group and the control group with respect to grades of p53 and bcl\u20102 expression (<jats:italic>P<\/jats:italic> &gt;0.05 for both). However, the CsA group showed a lower apoptosis grade than the control group (<jats:italic>P<\/jats:italic> &lt;0.05). None of the clinical parameters was significantly correlated with any of the immunohistochemical findings for p53 or bcl\u20102 (P &gt;0.05 for all). Similarly, grade of apoptosis was not correlated with any of the clinical parameters (<jats:italic>P<\/jats:italic> &gt;0.05). There was a significant positive correlation between serum CsA level and level of bcl\u20102 expression, but serum CsA was not significantly correlated with level of apoptosis or level of p53 expression.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The results indicate that the pathogenesis of CsA\u2010induced GO might involve inhibition of apoptosis, and overexpression of bcl\u20102 in the setting of high serum CsA. <jats:italic>J Periodontol 2005;76:691\u2010695<\/jats:italic>.<\/jats:p>","DOI":"10.1902\/jop.2005.76.5.691","type":"journal-article","created":{"date-parts":[[2005,5,18]],"date-time":"2005-05-18T05:45:34Z","timestamp":1116395134000},"page":"691-695","source":"Crossref","is-referenced-by-count":16,"title":["Effect of Cyclosporin A on Apoptosis and Expression of p53 and bcl\u20102 Proteins in the Gingiva of Renal Transplant Patients"],"prefix":"10.1002","volume":"76","author":[{"given":"\u015eule","family":"Bulut","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. Handan","family":"\u00d6zdemir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emine Elif","family":"Alaaddino\u011dlu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00fcsun Bahar","family":"Oduncuo\u011dlu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6mer Engin","family":"Bulut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beyhan","family":"Demirhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2005.76.5.691","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:18:33Z","timestamp":1760872713000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2005.76.5.691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["10.1902\/jop.2005.76.5.691"],"URL":"https:\/\/doi.org\/10.1902\/jop.2005.76.5.691","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,5]]}}}