{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T07:40:16Z","timestamp":1785224416538,"version":"3.55.0"},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Syndecans are cell surface heparan sulfate proteoglycans (PG) which can bind to and modulate the action of growth factors and extracellular matrix components (ECM). Syndecan\u2010 1 has been shown to play important roles during early tooth development and wound healing and repair. Among diverse cells and tissues that comprise the periodontium, the junctional epithelium (JE) constitutes a region of significant anatomic and clinical importance, but the nature of inductive signals and molecules involved in its formation is still unclear. Therefore, this work examines if syndecan\u20101 is associated with formation of JE, and the distribution of other syndecan family members in the epithelium.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold><jats:italic>In situ<\/jats:italic> hybridization and immunohistochemical techniques were performed using oral tissues from 4\u2010day\u2010old to 10\u2010week\u2010old mice to investigate the expression of syndecan\u2010 1, \u20102, \u20103 and \u20104 mRNAs and their corresponding proteins.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Based on <jats:italic>in situ<\/jats:italic> hybridization experiments, all syndecan mRNAs were detected in sulcular epithelium (SE), gingival epithelium (GE), and JE with varying intensity and distribution. Syndecan\u20101 immunostaining was localized on the cell surface while that of syndecan\u20102 did not show clear membrane localization. Our experiments in the developing tooth demonstrated that syndecan\u20101 protein followed characteristic patterns of expression during JE formation and that immunoreactivity for syndecan\u20101 protein decreased with age when JE cells underwent terminal differentiation.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Results of syndecan\u20101 mRNA and protein expression patterns suggested that this proteoglycan might be an important molecule during the formation of JE. <jats:italic>J Periodontol 2005;76:696\u2010704<\/jats:italic>.<\/jats:p>","DOI":"10.1902\/jop.2005.76.5.696","type":"journal-article","created":{"date-parts":[[2005,5,18]],"date-time":"2005-05-18T05:45:34Z","timestamp":1116395134000},"page":"696-704","source":"Crossref","is-referenced-by-count":14,"title":["Syndecan\u20101 Expression During the Formation of Junctional Epithelium"],"prefix":"10.1002","volume":"76","author":[{"given":"Rubia A.","family":"Dias","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunichi","family":"Shibata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Hashimoto\u2010Uoshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna A.","family":"Podyma\u2010Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Yanagishita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,5]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2005.76.5.696","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:18:33Z","timestamp":1760872713000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2005.76.5.696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["10.1902\/jop.2005.76.5.696"],"URL":"https:\/\/doi.org\/10.1902\/jop.2005.76.5.696","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,5]]}}}