{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T04:12:18Z","timestamp":1770696738973,"version":"3.49.0"},"reference-count":0,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Controversial data regarding the association between immunosuppression and prevalence\/ severity of periodontal diseases in HIV infection have been reported. Thus, the aim of this study was to test the hypothesis that lower T CD4 lymphocyte levels are not related to a higher prevalence of chronic periodontitis in HIV\u2010infected Brazilians undergoing highly active anti\u2010retroviral therapy (HAART).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Sixty\u2010four HIV\u2010infected patients under HAART were classified as having chronic periodontitis; i.e., \u2265three sites with probing depth (PD) and\/or clinical attachment level (CAL) \u22655 mm or periodontal healthy (no sites with PD &gt;3 mm and\/or CAL &gt;4 mm). All subjects received conventional periodontal therapy. Bleeding on probing, plaque accumulation, PD, and CAL were registered at six sites\/tooth at baseline and 4 months after therapy. Epidemiological features and levels of T CD4 lymphocytes were obtained from medical records. Significance of differences in periodontal clinical parameters within and between groups were determined using Wilcoxon signed\u2010rank and Mann\u2010Whitney or independent sample <jats:italic>t<\/jats:italic> tests. Associations between T CD4 levels and clinical parameters were determined using the chi square test.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Sixty\u2010one percent of the HIV\u2010infected patients represented AIDS cases, although 69% of them were periodontally healthy. The overall T CD4 lymphocyte mean levels was 333 \u00b1 254 cells\/mm<jats:sup>3<\/jats:sup> and viral load was 12,815 \u00b1 24,607 copies\/mm<jats:sup>3<\/jats:sup>. Yet the prevalence of chronic periodontitis was relatively low (36%). In addition, patients with periodontitis presented a moderate disease (mean PD = 2.2 \u00b1 0.10; mean CAL = 2.6 \u00b1 0.13) and responded successfully to periodontal therapy. These subjects showed higher levels of T CD4 cells, but lower counts of neutrophils than periodontally healthy patients. Among periodontally healthy and chronic periodontitis patients, 41.7% and 22.9%, respectively, had low levels of T CD4 lymphocytes. No significant differences between periodontal status and epidemiological and immunological parameters were observed.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Based on these results, the hypothesis that lower T CD4 lymphocyte levels are not associated with higher prevalence of chronic periodontitis in HIV\u2010infected Brazilians under HAART cannot be rejected. <jats:italic>J Periodontol 2005;76:915\u2010922<\/jats:italic>.<\/jats:p>","DOI":"10.1902\/jop.2005.76.6.915","type":"journal-article","created":{"date-parts":[[2005,6,13]],"date-time":"2005-06-13T06:41:37Z","timestamp":1118644897000},"page":"915-922","source":"Crossref","is-referenced-by-count":29,"title":["Association of T CD4 Lymphocyte Levels and Chronic Periodontitis in HIV\u2010Infected Brazilian Patients Undergoing Highly Active Anti\u2010Retroviral Therapy: Clinical Results"],"prefix":"10.1002","volume":"76","author":[{"given":"Lucio de Souza","family":"Gon\u00e7alves","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f4nia Maria Soares","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Arley","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"German Eduardo","family":"Villoria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00facia Helena","family":"Costinha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Paula","family":"Colombo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2005.76.6.915","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:18:07Z","timestamp":1760865487000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2005.76.6.915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["10.1902\/jop.2005.76.6.915"],"URL":"https:\/\/doi.org\/10.1902\/jop.2005.76.6.915","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6]]}}}