{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T16:46:59Z","timestamp":1785862019964,"version":"3.56.0"},"reference-count":0,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Reports have demonstrated that nutrient supplements, in particular vitamin\u2010B complex (Vit\u2010B), can positively influence wound healing processes. However, limited information is available on the effects of Vit\u2010B on periodontal wound healing.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A total of 30 patients (13 males, 17 females) presenting with generalized moderate to severe chronic periodontitis were enrolled in this study. All subjects presented \u2265 two teeth in the same sextant with probing depth (PD) \u22655 mm and bleeding upon probing (BOP) in need of access flap surgery (AFS). This study was a randomized, double\u2010masked, placebo\u2010controlled clinical trial. Subjects were instructed to take one capsule a day of either Vit\u2010B (50 mg of the following: thiamine HCl, riboflavin, niacinamide, d\u2010calcium pantothenate, and pyridoxine HCl; 50 \u00b5g each of d\u2010biotin and cyanocobalamin; and 400 mcg of folate) or placebo for 30 days following AFS. Clinical attachment levels (CAL) and N\u2010benzoyl\u2010dl\u2010arginine\u20102\u2010 naphthylamide (BANA) test scores were measured at baseline and at 90 and 180 days following surgical intervention. Assessments of the healing response were also performed using BOP, gingival index (GI), and plaque index (Pl) at baseline and 7, 14, 30, 90, and 180 days. The mean results of each parameter were averaged within a group. Differences between groups were analyzed by using repeated measures analysis of variance (ANOVA).<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Both groups experienced comparable levels of PD reduction following AFS (test: \u22121.57 \u00b1 0.34; control: \u22121.50 \u00b1 0.21). Changes in mean CAL were more favorable in Vit\u2010B supplemented subjects (test: +0.41 \u00b1 0.12; control: \u22120.52 \u00b1 0.23; <jats:italic>P<\/jats:italic> = 0.024). Stratified data demonstrated significantly better results for the test group in both shallow (test: \u22120.08 \u00b1 0.03; control: \u22121.11 \u00b1 0.27; <jats:italic>P<\/jats:italic> = 0.032) and deep sites (test: +1.69 \u00b1 0.31; control: +0.74 \u00b1 0.23; <jats:italic>P<\/jats:italic> = 0.037). No significant differences were observed between groups regarding PI, GI, and BOP. BANA test values were significantly reduced in both groups after surgical treatment and no significant differences were noted between groups.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Vitamin B\u2010complex supplement in combination with AFS resulted in statistically significant superior CAL gains when compared to placebo. <jats:italic>J Periodontol 2005;76:1084\u20101091<\/jats:italic>.<\/jats:p>","DOI":"10.1902\/jop.2005.76.7.1084","type":"journal-article","created":{"date-parts":[[2005,7,15]],"date-time":"2005-07-15T03:18:43Z","timestamp":1121397523000},"page":"1084-1091","source":"Crossref","is-referenced-by-count":91,"title":["Effects of Vitamin\u2010B Complex Supplementation on Periodontal Wound Healing"],"prefix":"10.1002","volume":"76","author":[{"given":"Rodrigo F.","family":"Neiva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalaf","family":"Al\u2010Shammari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Francisco H.","family":"Nociti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Soehren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hom\u2010Lay","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,7]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2005.76.7.1084","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:33:50Z","timestamp":1760870030000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2005.76.7.1084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2005,7]]}},"alternative-id":["10.1902\/jop.2005.76.7.1084"],"URL":"https:\/\/doi.org\/10.1902\/jop.2005.76.7.1084","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,7]]}}}