{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T07:09:15Z","timestamp":1772953755848,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Periodontitis shares several clinical and pathogenic characteristics with chronic arthritis, and there is some degree of coexistence. The aims of this study were to elucidate whether patients with localized aggressive periodontitis (LAgP), generalized aggressive periodontitis (GAgP), juvenile idiopathic arthritis (JIA), and rheumatoid arthritis (RA) share periodontal and hematological characteristics distinguishing them from individuals free of diseases.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The study population consisted of white adults (\u226435 years old) with LAgP (N = 18), GAgP (N = 27), JIA (N = 10), RA (N = 23), and healthy controls (N = 25). All individuals underwent a standardized interview, blood sampling, and an intraoral examination, including registration of plaque, bleeding on probing, probing depth (PD), clinical attachment loss (CAL), and alveolar bone loss (ABL) on radiographs. Blood samples were analyzed for erythrocyte fraction, leukocytes and differential counts, erythrocyte sedimentation rate, C\u2010reactive protein (CRP), immunoglobulin (Ig) M and IgA rheumatoid factors (RFs), and antibodies to cyclic citrullinated peptides.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> RA patients had a higher percentage of sites with PD \u22654 mm, CAL \u22652 mm, and ABL \u22652 mm compared to controls. The percentage of sites with CAL \u22652 mm significantly correlated with the levels of IgM\u2010RF and IgA\u2010RF. Missing teeth in JIA and RA patients were not lost due to periodontitis. Patients with GAgP showed higher levels of leukocytes, including neutrophils, and CRP compared to controls. In part, JIA and RA patients showed similar results.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Young adults with RA may develop periodontal destruction, and these patients require professional attention. Both differences and similarities in periodontal and hematological variables were seen in individuals with periodontitis, JIA, and RA.<\/jats:p>","DOI":"10.1902\/jop.2006.050051","type":"journal-article","created":{"date-parts":[[2006,2,6]],"date-time":"2006-02-06T14:53:47Z","timestamp":1139237627000},"page":"280-288","source":"Crossref","is-referenced-by-count":96,"title":["Periodontal and Hematological Characteristics Associated With Aggressive Periodontitis, Juvenile Idiopathic Arthritis, and Rheumatoid Arthritis"],"prefix":"10.1002","volume":"77","author":[{"given":"Anne","family":"Havemose\u2010Poulsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jytte","family":"Westergaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaj","family":"Stoltze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Skj\u00f8dt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bente","family":"Danneskiold\u2010Sams\u00f8e","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning","family":"Locht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Bendtzen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Palle","family":"Holmstrup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0720-048X(98)00038-2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.00371.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200009000-00011"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.11.1013"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411930040020401"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2478(94)00153-7"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411970080020801"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780401221"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027004267.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.6.779"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.00406.x"},{"key":"e_1_2_8_13_1","first-page":"50","volume-title":"ABC of Rheumatology","author":"Akil M","year":"2004"},{"key":"e_1_2_8_14_1","first-page":"68","volume-title":"ABC of Rheumatology","author":"Friswell M","year":"2004"},{"key":"e_1_2_8_15_1","first-page":"73","article-title":"Applications of acute phase reactants in infectious diseases","volume":"32","author":"Johnson HL","year":"1999","journal-title":"J Microbiol Immunol Infect"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1997.270-ce1162.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.10.1528"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.10.1172"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.72.9.1221"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200001)43:1<155::AID-ANR20>3.0.CO;2-3"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1316"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00918681"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1982.53.9.568"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.39"},{"issue":"25","key":"e_1_2_8_26_1","first-page":"1991","article-title":"Revision of the proposed classification criteria for juvenile idiopathic arthritis: Durban","volume":"1998","author":"Petty RE","year":"1997","journal-title":"J Rheumatol"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_8_28_1","first-page":"229","article-title":"Problems and proposals for recording gingivitis and plaque","volume":"25","author":"Ainamo J","year":"1975","journal-title":"Int Dent J"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1989.tb00623.x"},{"key":"e_1_2_8_30_1","first-page":"2585","article-title":"Prognostic factors for joint destruction in rheumatoid arthritis: A prospective longitudinal study of 318 patients","volume":"30","author":"Guillemin F","year":"2003","journal-title":"J Rheumatol"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10167"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.2.120"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009747509095615"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1989.tb00622.x"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1990.tb01091.x"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1992.tb01702.x"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd1959.34.89"},{"key":"e_1_2_8_38_1","first-page":"98","article-title":"Temporomandibular joint function in patients with longstanding rheumatoid arthritis \u2013 I. Role of periodontal status and prosthetic care \u2013 A clinical study","volume":"8","author":"Gleissner C","year":"2003","journal-title":"Eur J Med Res"},{"key":"e_1_2_8_39_1","first-page":"387","article-title":"The role of risk factors for periodontal disease in patients with rheumatoid arthritis","volume":"3","author":"Gleissner C","year":"1998","journal-title":"Eur J Med Res"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1981.tb00953.x"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1983.tb02201.x"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2000.2240112.x"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1984.tb00903.x"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330504"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/37.11.1157"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2006.050051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:09:29Z","timestamp":1760868569000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2006.050051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["10.1902\/jop.2006.050051"],"URL":"https:\/\/doi.org\/10.1902\/jop.2006.050051","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2]]}}}