{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T10:08:53Z","timestamp":1763201333141,"version":"build-2065373602"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The aim of this clinical study was to evaluate the association of locally delivered doxycycline 10% with scaling and root planing in the periodontal treatment of smokers during a 2\u2010year period.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Forty\u2010eight chronic periodontitis patients, presenting a minimum of four pockets (\u22655 mm) that bled on probing on anterior teeth were included. Patients were randomly assigned to receive one of the following treatments: scaling and root planing (SRP) and scaling and root planing followed by local application of doxycycline (SRP\u2010D). Assigned treatments were performed at baseline and at 12 months. Clinical parameters, including probing depth (PD) and relative attachment level (RAL), were recorded at baseline; 45 days; 3, 6, and 12 months (retreatment); 45 days following retreatment; and at 15, 18, and 24 months.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> In initially deep pockets (\u22657 mm), SRP\u2010D showed greater PD reduction than SRP at 6 and 18 months (mean difference between groups of 1.18 and 1.73 mm, respectively; <jats:italic>P &lt;<\/jats:italic>0.05) and greater RAL gain in all periods after 3 months (mean difference between groups of 1.16, 1.99, and 1.78 mm, at 6, 18, and 24 months, respectively; <jats:italic>P<\/jats:italic> &lt;0.05). Also, the proportion of sites showing \u22652 mm PD reduction was greater for SRP\u2010D at 6 months (81.2% \u00d7 50.8%; <jats:italic>P<\/jats:italic> &lt;0.001) and at 24 months (65.5% \u00d7 46.5%; <jats:italic>P<\/jats:italic> = 0.01). As for RAL gain, this proportion was 34.4% and 18.1% for SRP\u2010D and SRP at 24 months, respectively (<jats:italic>P<\/jats:italic> = 0.008).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The use of locally delivered doxycycline may constitute an important adjunct for the active and supportive treatments of severe periodontal disease in smokers.<\/jats:p>","DOI":"10.1902\/jop.2006.050087","type":"journal-article","created":{"date-parts":[[2006,4,3]],"date-time":"2006-04-03T12:17:31Z","timestamp":1144066651000},"page":"606-613","source":"Crossref","is-referenced-by-count":41,"title":["Locally Delivered Doxycycline as an Adjunctive Therapy to Scaling and Root Planing in the Treatment of Smokers: A 2\u2010Year Follow\u2010Up"],"prefix":"10.1002","volume":"77","author":[{"given":"Luciana","family":"Machion","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise Carleto","family":"Andia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovana","family":"Lecio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Francisco Humberto","family":"Nociti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcio Zaffalon","family":"Casati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Wilson","family":"Sallum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enilson Antonio","family":"Sallum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.5.490"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1988.59.12.783"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/08959374980120011501"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.6.657"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2001.280806.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.7.675"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1994.tb00285.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.5.467"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.1999.260305.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00524.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.3.464"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1994.0261"},{"key":"e_1_2_7_14_1","first-page":"109","article-title":"A study of scaling and root planing by scanning electron microscopy","volume":"50","author":"Walker SL","year":"1976","journal-title":"Dent Hyg"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.36.7.1347"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.1993.tb04345.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.280102.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.00375.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.11.1535"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2006.050087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:21:53Z","timestamp":1760876513000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2006.050087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["10.1902\/jop.2006.050087"],"URL":"https:\/\/doi.org\/10.1902\/jop.2006.050087","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"type":"print","value":"0022-3492"},{"type":"electronic","value":"1943-3670"}],"subject":[],"published":{"date-parts":[[2006,4]]}}}