{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T19:13:46Z","timestamp":1784402026926,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The aim of this clinical trial was to evaluate the effect of topically applied povidone\u2010iodine (polyvinylpyrrolidone and iodine [PVP\u2010I]) used as an adjunct to non\u2010surgical therapy of furcation involvements.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Forty\u2010four patients presenting at least one Class II furcation involvement that bled on probing with probing depth (PD) \u22655 mm were recruited. Patients were stratified into two treatment groups: 1) subgingival instrumentation by an ultrasonic device using PVP\u2010I (10%) as the cooling liquid (test); and 2) identical treatment using distilled water as the cooling liquid (control). The following clinical outcomes were evaluated: plaque index, bleeding on probing (BOP), position of the gingival margin, relative attachment level (RAL), PD, and relative horizontal attachment level (RHAL). The N\u2010benzoyl\u2010L\u2010arginine\u2010p\u2010nitroanilide (BAPNA) test was used to analyze the trypsin\u2010like activity in dental biofilm. The clinical and biochemical parameters were evaluated at baseline and 1, 3, and 6 months after therapy.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold>: Both groups had similar means of PD reduction and RAL and RHAL gain. At 6 months, these variables were, respectively, 2.31, 1.17, and 1.00 mm in the control group and 2.31, 1.23, and 1.02 mm in the test group. There was also no difference between groups regarding the number of furcation sites presenting RAL gain \u22652 mm. The results of the BAPNA test failed to demonstrate significant differences between groups.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Non\u2010surgical therapy can effectively treat Class II furcation involvements, and the use of topically applied PVP\u2010I as an adjunct to subgingival instrumentation does not provide additional benefits.<\/jats:p>","DOI":"10.1902\/jop.2006.050095","type":"journal-article","created":{"date-parts":[[2006,2,6]],"date-time":"2006-02-06T14:53:47Z","timestamp":1139237627000},"page":"211-217","source":"Crossref","is-referenced-by-count":35,"title":["Povidone\u2010Iodine Used as an Adjunct to Non\u2010Surgical Treatment of Furcation Involvements"],"prefix":"10.1002","volume":"77","author":[{"given":"\u00c9rica","family":"Del Peloso Ribeiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Bittencourt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glaucia Maria Bovi","family":"Ambrosano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Francisco H.","family":"Nociti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enilson A.","family":"Sallum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nio W.","family":"Sallum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcio 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